Phosphoric acid, diethyl 3-[4-[[2-[2-[[[[3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-5-thiazolyl] ethyl]amino]thieno[3,2-d]pyrimidin-6-yl]phenyl ester

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Chemical Name:Phosphoric acid, diethyl 3-[4-[[2-[2-[[[[3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-5-thiazolyl] ethyl]amino]thieno[3,2-d]pyrimidin-6-yl]phenyl ester
CAS No.:875798-59-7
Molecular Formula:C29H28F3N6O5PS2
Molecular Weight:748.787
Hs Code.:

Phosphoric acid, diethyl
3-[4-[[2-[2-[[[[3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-5-thiazolyl]
ethyl]amino]thieno[3,2-d]pyrimidin-6-yl]phenyl ester

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Chemical Property of Phosphoric acid, diethyl 3-[4-[[2-[2-[[[[3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-5-thiazolyl] ethyl]amino]thieno[3,2-d]pyrimidin-6-yl]phenyl ester

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Technology Process of Phosphoric acid, diethyl 3-[4-[[2-[2-[[[[3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-5-thiazolyl] ethyl]amino]thieno[3,2-d]pyrimidin-6-yl]phenyl ester

There total 1 articles about Phosphoric acid, diethyl 3-[4-[[2-[2-[[[[3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-5-thiazolyl] ethyl]amino]thieno[3,2-d]pyrimidin-6-yl]phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 875798-58-6
1-(5-{2-[6-(3-Hydroxy-phenyl)-thieno[3,2-d]pyrimidin-4-ylamino]-ethyl}-thiazol-2-yl)-3-(3-trifluoromethyl-phenyl)-urea

: 137709-66-1
di-tert-butyl N,N-diethylphosphoramidite

: 875798-59-7
phosphoric acid di-tert-butyl ester 3-[4-(2-{2-[3-(3-trifluoromethyl-phenyl)-ureido]-thiazol-5-yl}-ethylamino)-thieno[3,2-d]pyrimidin-6-yl]-phenyl ester

Guidance literature:: 1-(5-{2-[6-(3-Hydroxy-phenyl)-thieno[3,2-d]pyrimidin-4-ylamino]-ethyl}-thiazol-2-yl)-3-(3-trifluoromethyl-phenyl)-urea; di-tert-butyl N,N-diethylphosphoramidite; With 1H-tetrazole; In tetrahydrofuran; acetonitrile; at 20 ℃; for 3.5h;

With tert.-butylhydroperoxide; In tetrahydrofuran; water; acetonitrile; for 1h;

Reference yield:

: 875798-59-7
phosphoric acid di-tert-butyl ester 3-[4-(2-{2-[3-(3-trifluoromethyl-phenyl)-ureido]-thiazol-5-yl}-ethylamino)-thieno[3,2-d]pyrimidin-6-yl]-phenyl ester

: C₂₅H₁₈F₃N₆O₅PS₂^(2-)*2Na⁽¹⁺⁾

Guidance literature:: phosphoric acid di-tert-butyl ester 3-[4-(2-{2-[3-(3-trifluoromethyl-phenyl)-ureido]-thiazol-5-yl}-ethylamino)-thieno[3,2-d]pyrimidin-6-yl]-phenyl ester; With trifluoroacetic acid; In dichloromethane; at 20 ℃;

In water; acetonitrile; at 20 ℃; for 2h;