Hexanenitrile,6-hydroxy-

Base Information

Chemical Name:Hexanenitrile,6-hydroxy-
CAS No.:2453-48-7
Molecular Formula:C6H11 N O
Molecular Weight:113.159
Hs Code.:
Mol file:2453-48-7.mol

Synonyms:1-Hydroxy-5-cyanopentane;6-Hydroxyhexanenitrile; Pentamethylene cyanohydrin

Suppliers and Price of Hexanenitrile,6-hydroxy-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of Hexanenitrile,6-hydroxy-

Chemical Property:

PSA：44.02000
LogP:1.06268

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses 6-Hydroxyhexanenitrile is an intermediate in the synthesis of 6-?Chlorohexanenitrile (C350330). 6-?Chlorohexanenitrile is a reagent in the synthesis of dual histamine H1 and H2 receptor antagonists. Also used in the preparation of dual action MDR anthranilamide modulators with activity against CYP450, which can assist in tumor treatment.

Technology Process of Hexanenitrile,6-hydroxy-

There total 1 articles about Hexanenitrile,6-hydroxy- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.0%

: 4048-33-3
6-amino-1-hexanol

: 111-69-3
hexanedinitrile

: 2453-48-7
6-hydroxyhexanenitrile

Guidance literature:: With ammonia; iodine; In water; at 60 ℃; for 24h;
DOI:10.1055/s-2008-1067123

Reference yield: 68.0%

: 2453-48-7
6-hydroxyhexanenitrile

: 943230-31-7
4-chloro-5-(4-methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidine

: 943230-44-2
6-{[5-(4-methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]oxy}hexanenitrile

Guidance literature:: 6-hydroxyhexanenitrile; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃;

4-chloro-5-(4-methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidine; In N,N-dimethyl-formamide; mineral oil; at 120 ℃;

Reference yield: 66.0%

: 2453-48-7
6-hydroxyhexanenitrile

: 873-55-2
sodium benzenesulfonate

: 6-(phenylsulfonyl)hexanenitrile

Guidance literature:: 6-hydroxyhexanenitrile; With N-Bromosuccinimide; triphenylphosphine; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 0.75h; Inert atmosphere; Schlenk technique;

sodium benzenesulfonate; With sodium iodide; In N,N-dimethyl-formamide; at 80 ℃; Inert atmosphere; Schlenk technique;
DOI:10.1002/chem.202103866