Heptanoic acid, 3-[(1R)-1-cyano-1-[[(4S,5S)-2,2-dimethyl-4-phenyl-1,3-dioxan-5-yl]meth ylamino]propyl]-, methyl ester, (3R)-

Base Information

• Chemical Name: Heptanoic acid, 3-[(1R)-1-cyano-1-[[(4S,5S)-2,2-dimethyl-4-phenyl-1,3-dioxan-5-yl]meth ylamino]propyl]-, methyl ester, (3R)-
• CAS No.: 875927-08-5
• Molecular Formula: C₂₅H₃₈N₂O₄
• Molecular Weight: 430.588
• Mol file: 875927-08-5.mol

Synonyms:

Chemical Property of Heptanoic acid, 3-[(1R)-1-cyano-1-[[(4S,5S)-2,2-dimethyl-4-phenyl-1,3-dioxan-5-yl]meth ylamino]propyl]-, methyl ester, (3R)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Heptanoic acid, 3-[(1R)-1-cyano-1-[[(4S,5S)-2,2-dimethyl-4-phenyl-1,3-dioxan-5-yl]meth ylamino]propyl]-, methyl ester, (3R)-

There total 2 articles about Heptanoic acid, 3-[(1R)-1-cyano-1-[[(4S,5S)-2,2-dimethyl-4-phenyl-1,3-dioxan-5-yl]meth ylamino]propyl]-, methyl ester, (3R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

((4S,5S)-2,2-Dimethyl-4-phenyl-[1,3]dioxan-5-yl)-methyl-amine; hydrochloride → (R)-3-{(R)-1-Cyano-1-[((4S,5S)-2,2-dimethyl-4-phenyl-[1,3]dioxan-5-yl)-methyl-amino]-propyl}-heptanoic acid methyl ester (875927-08-5)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂O / 0 deg C -> room temp.

2: 1.) lithiumdiisopropylamide / 1.) n-hexane, ether, -78 deg -> 0 deg C, 0.5h, 2.) -100 deg C, 1h

With lithium diisopropyl amide; In water;

Reference yield:

(E)-methyl 2-heptenoate (22104-69-4,66618-64-2,38693-91-3) + 2-[((4S,5S)-2,2-Dimethyl-4-phenyl-[1,3]dioxan-5-yl)-methyl-amino]-butyronitrile (124686-42-6) → (R)-3-{(R)-1-Cyano-1-[((4S,5S)-2,2-dimethyl-4-phenyl-[1,3]dioxan-5-yl)-methyl-amino]-propyl}-heptanoic acid methyl ester (875927-08-5)

Guidance literature:

With lithium diisopropyl amide; Multistep reaction; 1.) n-hexane, ether, -78 deg -> 0 deg C, 0.5h, 2.) -100 deg C, 1h;

upstream raw materials:

(E)-methyl 2-heptenoate

2-[((4S,5S)-2,2-Dimethyl-4-phenyl-[1,3]dioxan-5-yl)-methyl-amino]-butyronitrile