(αE)-α-Ethylidene-1,2,3,3aα,4,5,6,7-octahydro-7α-hydroxy-3-methyl-3,7a-diazacyclohepta[jk]fluorene-5β-acetaldehyde

Base Information

Chemical Name:(αE)-α-Ethylidene-1,2,3,3aα,4,5,6,7-octahydro-7α-hydroxy-3-methyl-3,7a-diazacyclohepta[jk]fluorene-5β-acetaldehyde
CAS No.:56519-07-4
Molecular Formula:C20H24N2O2
Molecular Weight:324.4168
Hs Code.:
Mol file:56519-07-4.mol

Synonyms:(E)-2-((3aS,5R,7S)-7-Hydroxy-3-methyl-1,2,3,3a,4,5,6,7-octahydro-3,7a-diaza-cyclohepta[jk]fluoren-5-yl)-but-2-enal;Akagerin;Aragerin;2-(7-hydroxy-3-methyl-1,2,3,3a,4,5,6,7-octahydro-3,7a-diaza-cyclohepta[jk]fluoren-5-yl)-but-2-enal;akagerine;

Suppliers and Price of (αE)-α-Ethylidene-1,2,3,3aα,4,5,6,7-octahydro-7α-hydroxy-3-methyl-3,7a-diazacyclohepta[jk]fluorene-5β-acetaldehyde

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (αE)-α-Ethylidene-1,2,3,3aα,4,5,6,7-octahydro-7α-hydroxy-3-methyl-3,7a-diazacyclohepta[jk]fluorene-5β-acetaldehyde

Chemical Property:

Vapor Pressure:1.5E-12mmHg at 25°C
Melting Point:185 - 186 °C (ethyl acetate)
Boiling Point:541.3°Cat760mmHg
Flash Point:281.2°C
PSA：45.47000
Density:1.27g/cm³
LogP:3.15430

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (αE)-α-Ethylidene-1,2,3,3aα,4,5,6,7-octahydro-7α-hydroxy-3-methyl-3,7a-diazacyclohepta[jk]fluorene-5β-acetaldehyde

There total 10 articles about (αE)-α-Ethylidene-1,2,3,3aα,4,5,6,7-octahydro-7α-hydroxy-3-methyl-3,7a-diazacyclohepta[jk]fluorene-5β-acetaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: (-)-17-O-Methylakagerine

: 56519-07-4
akagerine

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; for 4h; Ambient temperature;
DOI:10.1021/jo00113a034

Reference yield: 88.0%

: C₂₇H₃₈N₂O₄Si

: 56519-07-4
(–)-akagerine

Guidance literature:: With tetrabutyl ammonium fluoride; acetic acid; In tetrahydrofuran; at 20 ℃; for 6.5h; Inert atmosphere;
DOI:10.1002/chem.202104052

Reference yield:

: C₁₆H₂₆O₅Si

: 56519-07-4
(–)-akagerine

Guidance literature:: Multi-step reaction with 4 steps

1: trifluoroacetic acid / dichloromethane / 1.5 h / 0 °C / Molecular sieve; Inert atmosphere

2: acetic acid; sodium cyanoborohydride / methanol / 60 h / 20 °C / Inert atmosphere

3: acetic acid / tetrahydrofuran; water / 3 h / -40 °C / Inert atmosphere

4: acetic acid; tetrabutyl ammonium fluoride / tetrahydrofuran / 6.5 h / 20 °C / Inert atmosphere

With tetrabutyl ammonium fluoride; sodium cyanoborohydride; acetic acid; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1002/chem.202104052