4,8-Dioxa-3,9-disilaundecane, 5-[[(2R,6R)-6-[2-[[(1,1-dimethylethyl)diphenylsilyl]oxy]ethyl]tetrahydro-2 H-pyran-2-yl]methyl]-7-[(2R,3S)-2-[(4-methoxyphenyl)methoxy]-3-methyl -4-pentynyl]-2,2,3,3,9,9,10,10-octamethyl-, (5S,7S)-

Base Information

Chemical Name:4,8-Dioxa-3,9-disilaundecane, 5-[[(2R,6R)-6-[2-[[(1,1-dimethylethyl)diphenylsilyl]oxy]ethyl]tetrahydro-2 H-pyran-2-yl]methyl]-7-[(2R,3S)-2-[(4-methoxyphenyl)methoxy]-3-methyl -4-pentynyl]-2,2,3,3,9,9,10,10-octamethyl-, (5S,7S)-
CAS No.:876144-60-4
Molecular Formula:C₅₃H₈₄O₆Si₃
Molecular Weight:901.503
Hs Code.:

4,8-Dioxa-3,9-disilaundecane,
5-[[(2R,6R)-6-[2-[[(1,1-dimethylethyl)diphenylsilyl]oxy]ethyl]tetrahydro-2
H-pyran-2-yl]methyl]-7-[(2R,3S)-2-[(4-methoxyphenyl)methoxy]-3-methyl
-4-pentynyl]-2,2,3,3,9,9,10,10-octamethyl-, (5S,7S)-

Synonyms:

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Chemical Property of 4,8-Dioxa-3,9-disilaundecane, 5-[[(2R,6R)-6-[2-[[(1,1-dimethylethyl)diphenylsilyl]oxy]ethyl]tetrahydro-2 H-pyran-2-yl]methyl]-7-[(2R,3S)-2-[(4-methoxyphenyl)methoxy]-3-methyl -4-pentynyl]-2,2,3,3,9,9,10,10-octamethyl-, (5S,7S)-

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Technology Process of 4,8-Dioxa-3,9-disilaundecane, 5-[[(2R,6R)-6-[2-[[(1,1-dimethylethyl)diphenylsilyl]oxy]ethyl]tetrahydro-2 H-pyran-2-yl]methyl]-7-[(2R,3S)-2-[(4-methoxyphenyl)methoxy]-3-methyl -4-pentynyl]-2,2,3,3,9,9,10,10-octamethyl-, (5S,7S)-

There total 15 articles about 4,8-Dioxa-3,9-disilaundecane, 5-[[(2R,6R)-6-[2-[[(1,1-dimethylethyl)diphenylsilyl]oxy]ethyl]tetrahydro-2 H-pyran-2-yl]methyl]-7-[(2R,3S)-2-[(4-methoxyphenyl)methoxy]-3-methyl -4-pentynyl]-2,2,3,3,9,9,10,10-octamethyl-, (5S,7S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (2R,6R)-2-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-6-[(2S,4S,6R,7S)-9,9-dibromo-2,4-bis-(tert-butyl-dimethyl-silanyloxy)-6-(4-methoxy-benzyloxy)-7-methyl-non-8-enyl]-tetrahydro-pyran

: 876144-60-4
(2R,6R)-2-[(2S,4S,6R,7S)-2,4-Bis-(tert-butyl-dimethyl-silanyloxy)-6-(4-methoxy-benzyloxy)-7-methyl-non-8-ynyl]-6-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-tetrahydro-pyran

Guidance literature:: With n-butyllithium; In tetrahydrofuran; at -30 ℃;
DOI:10.1055/s-2005-918449

Reference yield:

: 876144-62-6
(2R,3R)-3-(4-Methoxy-benzyloxy)-2-methyl-hex-5-enal

: 876144-60-4
(2R,6R)-2-[(2S,4S,6R,7S)-2,4-Bis-(tert-butyl-dimethyl-silanyloxy)-6-(4-methoxy-benzyloxy)-7-methyl-non-8-ynyl]-6-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-tetrahydro-pyran

Guidance literature:: Multi-step reaction with 6 steps

1.1: 98 percent / PPh₃ / CH₂Cl₂

2.1: O₂; CuCl / PdCl₂ / dimethylformamide; H₂O

3.1: (-)-Ipc₂BCl; Et₃N / diethyl ether

3.2: 79 percent / diethyl ether / -78 - -20 °C

4.1: 92 percent / Me₄NBH(OAc)3 / acetonitrile; acetic acid / -30 °C

5.1: 2,6-lutidine / CH₂Cl₂

6.1: n-BuLi / tetrahydrofuran / -30 °C

With 2,6-dimethylpyridine; n-butyllithium; oxygen; triethylamine; triphenylphosphine; (-)-diisopinocamphenylborane chloride; copper(l) chloride; tetramethylammonium triacetoxyborohydride; palladium dichloride; In tetrahydrofuran; diethyl ether; dichloromethane; water; acetic acid; N,N-dimethyl-formamide; acetonitrile; 1.1: Corey-Fuchs homologation / 2.1: Wacker oxidation;
DOI:10.1055/s-2005-918449

Reference yield:

: Benzoic acid (S)-4-hydroxy-1,3-dimethyl-2-oxo-hept-6-enyl ester

: 876144-60-4
(2R,6R)-2-[(2S,4S,6R,7S)-2,4-Bis-(tert-butyl-dimethyl-silanyloxy)-6-(4-methoxy-benzyloxy)-7-methyl-non-8-ynyl]-6-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-tetrahydro-pyran

Guidance literature:: Multi-step reaction with 10 steps

1.1: Sc(OTf)3 / toluene

2.1: NaBH₄ / methanol

3.1: K₂CO₃

4.1: NaIO₄ / methanol; various solvent(s) / pH 7

5.1: 98 percent / PPh₃ / CH₂Cl₂

6.1: O₂; CuCl / PdCl₂ / dimethylformamide; H₂O

7.1: (-)-Ipc₂BCl; Et₃N / diethyl ether

7.2: 79 percent / diethyl ether / -78 - -20 °C

8.1: 92 percent / Me₄NBH(OAc)3 / acetonitrile; acetic acid / -30 °C

9.1: 2,6-lutidine / CH₂Cl₂

10.1: n-BuLi / tetrahydrofuran / -30 °C

With 2,6-dimethylpyridine; sodium tetrahydroborate; sodium periodate; n-butyllithium; oxygen; potassium carbonate; triethylamine; triphenylphosphine; (-)-diisopinocamphenylborane chloride; copper(l) chloride; tetramethylammonium triacetoxyborohydride; scandium tris(trifluoromethanesulfonate); palladium dichloride; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; acetic acid; N,N-dimethyl-formamide; toluene; acetonitrile; 5.1: Corey-Fuchs homologation / 6.1: Wacker oxidation;
DOI:10.1055/s-2005-918449