(3R,8'aβ)-8'-Ethyl-1,2,2',3',6',7',8',8'a-octahydro-1-methyl-2-oxospiro[3H-indole-3,1'(5'H)-indolizine]-8'β-propanoic acid methyl ester

Base Information

Chemical Name:(3R,8'aβ)-8'-Ethyl-1,2,2',3',6',7',8',8'a-octahydro-1-methyl-2-oxospiro[3H-indole-3,1'(5'H)-indolizine]-8'β-propanoic acid methyl ester
CAS No.:23185-53-7
Molecular Formula:C₂₂H₃₀N₂O₃
Molecular Weight:370.492
Hs Code.:
Mol file:23185-53-7.mol

Synonyms:Spiro[3H-indole-3,1'(5'H)-indolizine]-8'-propanoicacid, 8'-ethyl-1,2,2',3',6',7',8',8'a-octahydro-1-methyl-2-oxo-, methyl ester,[1'S-(1'a,8'a,8'aa)]-; Vincatine (7CI,8CI); (-)-Vincatine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3R,8'aβ)-8'-Ethyl-1,2,2',3',6',7',8',8'a-octahydro-1-methyl-2-oxospiro[3H-indole-3,1'(5'H)-indolizine]-8'β-propanoic acid methyl ester

Chemical Property:

PSA：49.85000
LogP:3.12140

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (3R,8'aβ)-8'-Ethyl-1,2,2',3',6',7',8',8'a-octahydro-1-methyl-2-oxospiro[3H-indole-3,1'(5'H)-indolizine]-8'β-propanoic acid methyl ester

There total 7 articles about (3R,8'aβ)-8'-Ethyl-1,2,2',3',6',7',8',8'a-octahydro-1-methyl-2-oxospiro[3H-indole-3,1'(5'H)-indolizine]-8'β-propanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 88377-52-0
C₂₂H₂₈N₂O₄

: 23185-53-7
(-)-Vincatine

Guidance literature:: Multi-step reaction with 2 steps

1: 38 percent / potassium azodicarboxylate, acetic acid / methanol / 10 h / Ambient temperature

2: 35 mg / W-2 Raney nickel / 1,2-dimethoxy-ethane / Ambient temperature

With potassium diazodicarboxylate; acetic acid; W-2 Raney nickel; In methanol; 1,2-dimethoxyethane;
DOI:10.1021/jo00177a033

Reference yield:

: 83532-51-8,83572-37-6,83572-38-7,83572-39-8,86852-35-9
C₂₂H₂₈N₂O₃S

: 23185-53-7,83572-40-1,83572-41-2,83572-42-3,83572-43-4,88424-29-7,88424-30-0,88424-31-1
(-)-Vincatine

Guidance literature:: With nickel; In tetrahydrofuran;
DOI:10.1016/S0040-4039(00)81965-6

Reference yield:

: 26126-79-4,82950-96-7,82950-97-8,82950-98-9,86852-36-0
C₂₂H₂₈N₂O₄

: 23185-53-7,83572-40-1,83572-41-2,83572-42-3,83572-43-4,88424-29-7,88424-30-0,88424-31-1
(-)-Vincatine

Guidance literature:: Multi-step reaction with 2 steps

1: P₄S₁₀ / pyridine / Heating

2: Raney Ni / tetrahydrofuran

With tetraphosphorus decasulfide; nickel; In tetrahydrofuran; pyridine;
DOI:10.1016/S0040-4039(00)81965-6