N-Hydroxy-2-naphthalenecarboxamide

Base Information

• Chemical Name: N-Hydroxy-2-naphthalenecarboxamide
• CAS No.: 10335-79-2
• Molecular Formula: C11H9 N O2
• Molecular Weight: 187.198
• Hs Code.: 2924299090
• UNII: VE8NEC3VME
• DSSTox Substance ID: DTXSID70145795
• Nikkaji Number: J932F
• Wikidata: Q83010435
• ChEMBL ID: CHEMBL156672
• Mol file: 10335-79-2.mol

Synonyms:2-naphthohydroxamic acid;N,N-naphthaloylhydroxylamine

Chemical Property of N-Hydroxy-2-naphthalenecarboxamide

Chemical Property:

• Melting Point: 168°C
• Refractive Index: 1.4900 (estimate)
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 52.82000
• Density: 1.291g/cm³
• LogP: 2.53360
• XLogP3: 2.5
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 187.063328530
• Heavy Atom Count: 14
• Complexity: 217

Purity/Quality:

98%,99%, ^*data from raw suppliers

N-HYDROXYNAPHTHALENE-2-CARBOXAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C2C=C(C=CC2=C1)C(=O)NO

Technology Process of N-Hydroxy-2-naphthalenecarboxamide

There total 8 articles about N-Hydroxy-2-naphthalenecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.6%

→ naphthalene-2-carboxylic acid hydroxyamide (10335-79-2)

Guidance literature:

Reference yield: 60.0%

2-naphthaloyl chloride (2243-83-6) → naphthalene-2-carboxylic acid hydroxyamide (10335-79-2)

Guidance literature:

With hydroxylamine hydrochloride; potassium carbonate; In water; ethyl acetate; at 0 - 20 ℃; for 16h;

DOI:10.1039/c8ob00490k

Reference yield:

naphthalene-2-carboxylate (93-09-4) → naphthalene-2-carboxylic acid hydroxyamide (10335-79-2)

Guidance literature:

With oxalyl dichloride; hydroxylamine hydrochloride; triethylamine; N,N-dimethyl-formamide; Yield given. Multistep reaction; 1.) CH₂Cl₂, 0 deg C, 40 min, 2.) CH₂Cl₂, THF, H₂O, 30 min;

DOI:10.1021/jm00386a022

upstream raw materials:

naphthalene-2-carboxylate

N-(2'-naphthoyl)imidazole

2-naphthaloyl chloride

methyl naphthalene-2-carboxylate

Downstream raw materials:

N-(2-formylphenyl)-2-naphthamide

BPA

3,4-diphenylbenzo[g]isoquinolin-1(2H)-one

C₁₃H₁₁NO₃