Urea, N-[[2-[[3-(3-chloro-2-hydroxyphenyl)-1,2,4-triazolo[4,3-a]pyridin-6-yl]thio] phenyl]methyl]-N'-[3-(1,1-dimethylethyl)-1-(3-methylphenyl)-1H-pyrazol-5 -yl]-

Base Information

Chemical Name:Urea, N-[[2-[[3-(3-chloro-2-hydroxyphenyl)-1,2,4-triazolo[4,3-a]pyridin-6-yl]thio] phenyl]methyl]-N'-[3-(1,1-dimethylethyl)-1-(3-methylphenyl)-1H-pyrazol-5 -yl]-
CAS No.:876299-08-0
Molecular Formula:C34H32ClN7O2S
Molecular Weight:638.193
Hs Code.:

Urea,
N-[[2-[[3-(3-chloro-2-hydroxyphenyl)-1,2,4-triazolo[4,3-a]pyridin-6-yl]thio]
phenyl]methyl]-N'-[3-(1,1-dimethylethyl)-1-(3-methylphenyl)-1H-pyrazol-5
-yl]-

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Chemical Property of Urea, N-[[2-[[3-(3-chloro-2-hydroxyphenyl)-1,2,4-triazolo[4,3-a]pyridin-6-yl]thio] phenyl]methyl]-N'-[3-(1,1-dimethylethyl)-1-(3-methylphenyl)-1H-pyrazol-5 -yl]-

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Technology Process of Urea, N-[[2-[[3-(3-chloro-2-hydroxyphenyl)-1,2,4-triazolo[4,3-a]pyridin-6-yl]thio] phenyl]methyl]-N'-[3-(1,1-dimethylethyl)-1-(3-methylphenyl)-1H-pyrazol-5 -yl]-

There total 10 articles about Urea, N-[[2-[[3-(3-chloro-2-hydroxyphenyl)-1,2,4-triazolo[4,3-a]pyridin-6-yl]thio] phenyl]methyl]-N'-[3-(1,1-dimethylethyl)-1-(3-methylphenyl)-1H-pyrazol-5 -yl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 1344738-26-6
1-[2-({3-[2-(benzyloxy)-3-chlorophenyl][1,2,4]triazolo[4,3-a]pyridin-6-yl}thio)benzyl]-3-[3-tert-butyl-1-(3-methylphenyl)-1H-pyrazol-5-yl]urea

: 876299-08-0
1-[3-tert-butyl-1-(3-methylphenyl)-1H-pyrazol-5-yl]-3-(2-{[3-(3-chloro-2-hydroxyphenyl)[1,2,4]triazolo[4,3-a]pyridin-6-yl]thio}benzyl)urea

Guidance literature:: With boron tribromide; In dichloromethane; at 0 ℃; for 0.5h; Inert atmosphere;
DOI:10.1021/jm200677b

Reference yield:

: C₂₇H₂₂ClN₃O₄S₂

: 876299-08-0
1-[3-tert-butyl-1-(3-methylphenyl)-1H-pyrazol-5-yl]-3-(2-{[3-(3-chloro-2-hydroxyphenyl)[1,2,4]triazolo[4,3-a]pyridin-6-yl]thio}benzyl)urea

Guidance literature:: Multi-step reaction with 3 steps

1: ammonia / methanol / 16 h / 20 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C / Inert atmosphere

3: boron tribromide / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

With ammonia; boron tribromide; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane;
DOI:10.1021/jm200677b

Reference yield:

: 1344738-12-0
2-(benzyloxy)-3-chlorobenzaldehyde (5-bromopyridin-2-yl)hydrazone

: 876299-08-0
1-[3-tert-butyl-1-(3-methylphenyl)-1H-pyrazol-5-yl]-3-(2-{[3-(3-chloro-2-hydroxyphenyl)[1,2,4]triazolo[4,3-a]pyridin-6-yl]thio}benzyl)urea

Guidance literature:: Multi-step reaction with 6 steps

1: [bis(acetoxy)iodo]benzene / ethanol; dichloromethane / 3 h / 20 °C

2: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate / N,N-dimethyl-formamide / 2 h / 90 °C / Inert atmosphere

3: dichloromethane / 2 h / 20 °C / Inert atmosphere

4: ammonia / methanol / 16 h / 20 °C / Inert atmosphere

5: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C / Inert atmosphere

6: boron tribromide / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; [bis(acetoxy)iodo]benzene; ammonia; boron tribromide; caesium carbonate; N-ethyl-N,N-diisopropylamine; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm200677b