Oxiranemethanol, 2-[2-(4-octylphenyl)ethyl]-, (2R)-

Base Information

Chemical Name:Oxiranemethanol, 2-[2-(4-octylphenyl)ethyl]-, (2R)-
CAS No.:876391-74-1
Molecular Formula:C19H30O2
Molecular Weight:290.446
Hs Code.:

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Oxiranemethanol, 2-[2-(4-octylphenyl)ethyl]-, (2R)-

Chemical Property:

Purity/Quality:

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MSDS Files:: SDS file from LookChem

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Technology Process of Oxiranemethanol, 2-[2-(4-octylphenyl)ethyl]-, (2R)-

There total 9 articles about Oxiranemethanol, 2-[2-(4-octylphenyl)ethyl]-, (2R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 876391-69-4
2-methylene-4-(4'-octylphenyl)butan-1-ol

: 876391-74-1
(2R)-2-(oxiranyl)-4-(4'-octylphenyl)butan-1-ol

Guidance literature:: With Cumene hydroperoxide; D-(-)-diisopropyl tartrate; titanium(IV) isopropylate; In dichloromethane; at -20 ℃;
DOI:10.1016/j.tetlet.2005.11.092

Reference yield:

: 49763-66-8
4-octylbenzaldehyde

: 876391-74-1
(2R)-2-(oxiranyl)-4-(4'-octylphenyl)butan-1-ol

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-butyllithium / tetrahydrofuran / 3 h / -78 °C / Inert atmosphere

1.2: 2 h / -78 - 20 °C / Inert atmosphere

2.1: tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

3.1: sodium hydroxide / tetrahydrofuran; water / 1 h / 0 - 20 °C / Inert atmosphere

3.2: 3 h / 60 °C / Inert atmosphere

4.1: hydrogenchloride; water / methanol / 1 h / 20 °C / Inert atmosphere

5.1: titanium(IV) isopropylate; D-(-)-diisopropyl tartrate / Inert atmosphere

With titanium(IV) isopropylate; hydrogenchloride; n-butyllithium; water; D-(-)-diisopropyl tartrate; sodium hydroxide; In tetrahydrofuran; methanol; water; 1.2: |Wittig Olefination / 3.2: |Suzuki Coupling / 5.1: |Sharpless Asymmetric Epoxidation;
DOI:10.1016/j.bmc.2013.02.042

Reference yield:

: 876391-67-2
((E)-4-Oct-1-enyl)-benzaldehyde

: 876391-74-1
(2R)-2-(oxiranyl)-4-(4'-octylphenyl)butan-1-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-BuLi / tetrahydrofuran

1.2: 81 percent / H₂ / Pd(OH)2/C / methanol

2.1: PCC; NaOAc; molecular sieves / CH₂Cl₂

2.2: 76 percent / Et₃N / CH₂Cl₂

3.1: 87 percent / NaBH₄ / CeCl₃ / methanol

4.1: 83 percent / (-)-DIPT; cumene hydroperoxide; MS / Ti(OPr-i)4 / CH₂Cl₂ / -20 °C

With sodium tetrahydroborate; n-butyllithium; molecular sieve; Cumene hydroperoxide; sodium acetate; D-(-)-diisopropyl tartrate; pyridinium chlorochromate; titanium(IV) isopropylate; cerium(III) chloride; In tetrahydrofuran; methanol; dichloromethane; 1.1: Wittig reaction / 2.2: Mannich reaction / 4.1: asymmetric Sharpless epoxidation;
DOI:10.1016/j.tetlet.2005.11.092