N-[1-(2-methylphenyl)ethylidene]hydroxylamine

Base Information

• Chemical Name: N-[1-(2-methylphenyl)ethylidene]hydroxylamine
• CAS No.: 27810-08-8
• Molecular Formula: C9H11 N O
• Molecular Weight: 149.192
• DSSTox Substance ID: DTXSID90950489
• Mol file: 27810-08-8.mol

Synonyms:N-[1-(2-methylphenyl)ethylidene]hydroxylamine;27810-08-8;DTXSID90950489;AKOS017263545

Chemical Property of N-[1-(2-methylphenyl)ethylidene]hydroxylamine

Chemical Property:

• Vapor Pressure: 0.00435mmHg at 25°C
• Boiling Point: 266.3°Cat760mmHg
• Flash Point: 154.4°C
• Density: 1g/cm³
• XLogP3: 2.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 149.084063974
• Heavy Atom Count: 11
• Complexity: 154

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=CC=C1C(=NO)C

Technology Process of N-[1-(2-methylphenyl)ethylidene]hydroxylamine

There total 11 articles about N-[1-(2-methylphenyl)ethylidene]hydroxylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

1-methyl-2-vinyl-benzene (611-15-4) → 1-(2-methylphenyl)ethanone oxime (27810-08-8)

Guidance literature:

With ethyl nitrite; tetraethylammonium borohydride; In benzene; for 28h; Ambient temperature;

DOI:10.1021/jo00256a001

Reference yield: 92.0%

2-Methylacetophenone (577-16-2,122382-54-1) → 1-(2-methylphenyl)ethanone oxime (27810-08-8)

Guidance literature:

With hydroxylamine hydrochloride; sodium hydroxide; In ethanol; water; for 1.5h; Heating; Inert atmosphere;

DOI:10.1039/c7ob02385e

Reference yield: 45.0%

1-ethynyl-2-methylbenzene (766-47-2) → 2-(o-tolyl)acetaldehyde oxime (596127-37-6) + 1-(2-methylphenyl)ethanone oxime (27810-08-8)

Guidance literature:

With hydroxylamine; In 1,4-dioxane; water; at 113 ℃; regioselective reaction; Inert atmosphere;

DOI:10.1021/ja806300r

upstream raw materials:

2-methylcinnamic acid

1-methyl-2-vinyl-benzene

Nitroethane

toluene

Downstream raw materials:

o-toluidine

2-Methylacetophenone

1,8-dimethyl-3,4-diphenylisoquinoline

[1-o-Tolyl-eth-(E)-ylideneaminooxy]-ethaneperoxoic acid tert-butyl ester