Technology Process of 7,9-Dioxa-1-azaspiro[4.5]dec-3-en-2-one,
1-chloro-3-methyl-6-(1-methylethyl)-8-phenyl-, (5R,6S,8R)-
There total 9 articles about 7,9-Dioxa-1-azaspiro[4.5]dec-3-en-2-one,
1-chloro-3-methyl-6-(1-methylethyl)-8-phenyl-, (5R,6S,8R)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium chlorite;
In
water; tert-butyl alcohol;
at 0 ℃;
for 18h;
DOI:10.1021/jo7027695
- Guidance literature:
-
With
sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene;
In
tert-butyl alcohol;
at 0 ℃;
DOI:10.1039/b516311k
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 78 percent / PPTS / benzene / Heating
2: 100 percent / H2 / Lindlar catalyst / methanol / 20 °C
3: MnO2; 4 Angstroem molecular sieves / CH2Cl2 / Heating
4: NaCNBH3; AcOH / methanol / 0 °C
5: 83 percent / KHMDS / tetrahydrofuran; toluene / 6 h / -30 °C
6: 93 percent / TPAP; 4-Angstroem molecular sieves; NMO / acetonitrile
7: aq. NaClO2; NaH2PO4; 2-methyl-2-butene / 2-methyl-propan-2-ol / 0 °C
With
manganese(IV) oxide; sodium chlorite; sodium dihydrogenphosphate; N-methyl-2-indolinone; tetrapropylammonium perruthennate; 2-methyl-but-2-ene; 4 A molecular sieve; hydrogen; pyridinium p-toluenesulfonate; potassium hexamethylsilazane; sodium cyanoborohydride; acetic acid;
Lindlar's catalyst;
In
tetrahydrofuran; methanol; dichloromethane; toluene; acetonitrile; tert-butyl alcohol; benzene;
DOI:10.1039/b516311k
