(1R,2R)-2-Amino-1-phenylpropan-1-ol;hydrochloride

Base Information

• Chemical Name: (1R,2R)-2-Amino-1-phenylpropan-1-ol;hydrochloride
• CAS No.: 53643-20-2
• Deprecated CAS: 4345-16-8,7587-43-1
• Molecular Formula: C9H13 N O . Cl H
• Molecular Weight: 187.669
• European Community (EC) Number: 205-826-7
• UN Number: 2811
• NCI Thesaurus Code: C66379
• Mol file: 53643-20-2.mol

Synonyms:Dexatrim;Hydrochloride, Phenylpropanolamine;Norephedrine;Phenylpropanolamine;Phenylpropanolamine Hydrochloride;Prolamine;Propagest;Triaminic DM

 This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.

Chemical Property of (1R,2R)-2-Amino-1-phenylpropan-1-ol;hydrochloride

Chemical Property:

• Melting Point: 178-179 °C(Solv: ethanol (64-17-5); ethyl ether (60-29-7)(1:2))
• Boiling Point: 288.1°Cat760mmHg
• Flash Point: 128.1°C
• PSA: 46.25000
• Density: 1.071g/cm³
• LogP: 2.56950
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 187.0763918
• Heavy Atom Count: 12
• Complexity: 110
• Transport DOT Label: Poison

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C(C1=CC=CC=C1)O)N.Cl
• Isomeric SMILES: C[C@H]([C@@H](C1=CC=CC=C1)O)N.Cl

Technology Process of (1R,2R)-2-Amino-1-phenylpropan-1-ol;hydrochloride

There total 17 articles about (1R,2R)-2-Amino-1-phenylpropan-1-ol;hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

(1S,2R)-(+)-norphedrine (37577-28-9,58550-13-3,757124-50-8) → (1R,2R)-norephedrine hydrochloride (53643-20-2)

Guidance literature:

(1S,2R)-(+)-norphedrine; With benzoyl chloride; triethylamine; In dichloromethane; at 20 ℃; for 3h;

With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; for 18h;

With hydrogenchloride; for 120h; Further stages.;

DOI:10.1039/b700477j

Reference yield: 74.0%

threo-1-benzoyloxy-1-phenyl-2-propylammonium chloride (38222-78-5) → threo-1-phenyl-1-hydroxy-2-propylammonium chloride (154-41-6,1485-15-0,2153-98-2,3198-15-0,4345-16-8,40626-29-7,53631-70-2,53643-20-2,54705-32-7)

Guidance literature:

With hydrogenchloride; for 30h; Heating;

Reference yield: 74.0%

trans-2,5-diphenyl-4-methyl-1,3-oxazoline (38222-77-4) → threo-1-phenyl-1-hydroxy-2-propylammonium chloride (154-41-6,1485-15-0,2153-98-2,3198-15-0,4345-16-8,40626-29-7,53631-70-2,53643-20-2,54705-32-7)

Guidance literature:

With hydrogenchloride; for 30h; Heating;

upstream raw materials:

2-nitro-1-phenylpropan-1-ol

(1RS,2RS)-2-dibenzylamino-1-phenyl-propan-1-ol; hydrochloride

benzaldehyde

(RS)-mandelonitrile

Downstream raw materials:

(1R,2R)-N-(2-hydroxy-1-methyl-2-phenylethyl)acrylamide

(1S,2R)-(+)-norphedrine

(1R,2S)-norephedrine

(1R,2S)-(-)-norephedrine hydrochloride