1,2-Pyrrolidinedicarboxylic acid, 4-(methylthio)-, 1-(1,1-dimethylethyl) ester, (2S,4R)-

Base Information

Chemical Name:1,2-Pyrrolidinedicarboxylic acid, 4-(methylthio)-, 1-(1,1-dimethylethyl) ester, (2S,4R)-
CAS No.:876953-58-1
Molecular Formula:C11H19NO4S
Molecular Weight:261.33800
Hs Code.:

Synonyms:(2S,4R)-4-Methylsulfanyl-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester;

Suppliers and Price of 1,2-Pyrrolidinedicarboxylic acid, 4-(methylthio)-, 1-(1,1-dimethylethyl) ester, (2S,4R)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Matrix Scientific
(4R)-1-Boc-4-methylthiol-L-proline 95+%
1g
$ 2574.00

Crysdot
(4R)-1-Boc-4-methylthiol-L-proline 95+%
1g
$ 1516.00

Total 5 raw suppliers

Chemical Property of 1,2-Pyrrolidinedicarboxylic acid, 4-(methylthio)-, 1-(1,1-dimethylethyl) ester, (2S,4R)-

Chemical Property:

PSA：92.14000
LogP:1.74990

Purity/Quality:

97% ^*data from raw suppliers

(4R)-1-Boc-4-methylthiol-L-proline 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1,2-Pyrrolidinedicarboxylic acid, 4-(methylthio)-, 1-(1,1-dimethylethyl) ester, (2S,4R)-

There total 6 articles about 1,2-Pyrrolidinedicarboxylic acid, 4-(methylthio)-, 1-(1,1-dimethylethyl) ester, (2S,4R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 188111-18-4
1-(tert-butyl) 2-methyl (2S,4R)-4-(acetylthio)pyrrolidine-1,2-dicarboxylate

: 77-78-1
dimethyl sulfate

: 876953-58-1
N-(tert-butyloxycarbonyl)-trans-4-(methylthio)-L-proline

Guidance literature:: With sodium hydroxide; In methanol; at 20 ℃; for 3.5h;
DOI:10.1016/j.bmc.2005.11.001

Reference yield:

: 13726-69-7,946610-68-0
(2S,4R)-4-hydroxy-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid

: 876953-58-1
N-(tert-butyloxycarbonyl)-trans-4-(methylthio)-L-proline

Guidance literature:: Multi-step reaction with 6 steps

1: 35 percent / CrO₃; pyridine / CH₂Cl₂ / 0.5 h / 0 °C

2: 97 percent / NaBH₄ / methanol; H₂O / 15 h / 4 °C

3: 63 percent / methanol; diethyl ether

4: 97 percent / Et₃N / CH₂Cl₂ / 0.33 h

5: 83 percent / dimethylformamide / 4 h / 68 °C

6: 87 percent / aq. NaOH / methanol / 3.5 h / 20 °C

With pyridine; chromium(VI) oxide; sodium hydroxide; sodium tetrahydroborate; triethylamine; In methanol; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2005.11.001

Reference yield:

: 74844-91-0,114676-69-6,135042-17-0,227935-38-8,102195-79-9
(2S,4S)-N-tert-butoxycarbonyl-4-hydroxyproline methyl ester

: 876953-58-1
N-(tert-butyloxycarbonyl)-trans-4-(methylthio)-L-proline

Guidance literature:: Multi-step reaction with 3 steps

1: 97 percent / Et₃N / CH₂Cl₂ / 0.33 h

2: 83 percent / dimethylformamide / 4 h / 68 °C

3: 87 percent / aq. NaOH / methanol / 3.5 h / 20 °C

With sodium hydroxide; triethylamine; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2005.11.001