1-Piperazinecarboxylic acid, 4-[2-[[2-[4-[2-(4-morpholinyl)ethoxy]phenyl]-3-phenylfuro[2,3-b]pyridin-4- yl]amino]ethyl]-, 1,1-dimethylethyl ester

Base Information

Chemical Name:1-Piperazinecarboxylic acid, 4-[2-[[2-[4-[2-(4-morpholinyl)ethoxy]phenyl]-3-phenylfuro[2,3-b]pyridin-4- yl]amino]ethyl]-, 1,1-dimethylethyl ester
CAS No.:877058-78-1
Molecular Formula:C36H45N5O5
Molecular Weight:627.784
Hs Code.:

1-Piperazinecarboxylic acid,
4-[2-[[2-[4-[2-(4-morpholinyl)ethoxy]phenyl]-3-phenylfuro[2,3-b]pyridin-4-
yl]amino]ethyl]-, 1,1-dimethylethyl ester

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Chemical Property of 1-Piperazinecarboxylic acid, 4-[2-[[2-[4-[2-(4-morpholinyl)ethoxy]phenyl]-3-phenylfuro[2,3-b]pyridin-4- yl]amino]ethyl]-, 1,1-dimethylethyl ester

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Technology Process of 1-Piperazinecarboxylic acid, 4-[2-[[2-[4-[2-(4-morpholinyl)ethoxy]phenyl]-3-phenylfuro[2,3-b]pyridin-4- yl]amino]ethyl]-, 1,1-dimethylethyl ester

There total 7 articles about 1-Piperazinecarboxylic acid, 4-[2-[[2-[4-[2-(4-morpholinyl)ethoxy]phenyl]-3-phenylfuro[2,3-b]pyridin-4- yl]amino]ethyl]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 877058-67-8
7-benzyl-2-(4-benzyloxy-phenyl)-3-phenyl-7H-furo[2,3-b]pyridin-4-one

: 877058-78-1
4-(2-{2-[4-(2-morpholin-4-yl-ethoxy)-phenyl]-3-phenyl-furo[2,3-b]pyridin-4-ylamino}-ethyl)-piperazine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 86 percent / H₂ / Pd/C / ethyl acetate; CH₂Cl₂ / 16 h / 20 °C

2: 65 percent / oxalyl chloride; DMF / CHCl₃ / 2 h / Heating

3: K₂CO₃; BINAP / Pd(OAc)2 / toluene / 18 h / 130 °C

4: Cs₂CO₃ / dimethylformamide / 16 h / 85 °C

With oxalyl dichloride; hydrogen; potassium carbonate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; N,N-dimethyl-formamide; palladium diacetate; palladium on activated charcoal; In dichloromethane; chloroform; ethyl acetate; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.bmcl.2007.01.048

Reference yield:

: 877058-69-0
C₁₉H₁₃NO₃

: 877058-78-1
4-(2-{2-[4-(2-morpholin-4-yl-ethoxy)-phenyl]-3-phenyl-furo[2,3-b]pyridin-4-ylamino}-ethyl)-piperazine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 65 percent / oxalyl chloride; DMF / CHCl₃ / 2 h / Heating

2: K₂CO₃; BINAP / Pd(OAc)2 / toluene / 18 h / 130 °C

3: Cs₂CO₃ / dimethylformamide / 16 h / 85 °C

With oxalyl dichloride; potassium carbonate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; N,N-dimethyl-formamide; palladium diacetate; In chloroform; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.bmcl.2007.01.048

Reference yield:

: 877058-70-3
4-(4-chloro-3-phenyl-furo[2,3-b]pyridin-2-yl)-phenol

: 877058-78-1
4-(2-{2-[4-(2-morpholin-4-yl-ethoxy)-phenyl]-3-phenyl-furo[2,3-b]pyridin-4-ylamino}-ethyl)-piperazine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: K₂CO₃; BINAP / Pd(OAc)2 / toluene / 18 h / 130 °C

2: Cs₂CO₃ / dimethylformamide / 16 h / 85 °C

With potassium carbonate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; palladium diacetate; In N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.bmcl.2007.01.048