Propanedioic acid, methyl(4-methylphenyl)-, monomethyl ester

Base Information

Chemical Name:Propanedioic acid, methyl(4-methylphenyl)-, monomethyl ester
CAS No.:877077-49-1
Molecular Formula:C12H14O4
Molecular Weight:222.241
Hs Code.:

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Propanedioic acid, methyl(4-methylphenyl)-, monomethyl ester

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Technology Process of Propanedioic acid, methyl(4-methylphenyl)-, monomethyl ester

There total 3 articles about Propanedioic acid, methyl(4-methylphenyl)-, monomethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 127047-04-5
dimethyl 2-methyl-2-(4-methylphenyl)malonate

: 877077-49-1
(R)-(+)-2-(methoxycarbonyl)-2-(4-methylphenyl)propionic acid

Guidance literature:: With sodium hydroxide; In water; at 25 ℃; for 1h; pig liver esterase, pH 7.2;
DOI:10.1021/jo00038a041

Reference yield:

: 79443-97-3
methyl 2-(4-methylphenyl)propanoate

: 877077-49-1
(R)-(+)-2-(methoxycarbonyl)-2-(4-methylphenyl)propionic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 1) i-Pr₂NH, n-BuLi / 1) THF, -78 deg C, 1 h, 2) 0 deg C, 30 min

2: 95 percent / 2N NaOH / H₂O / 1 h / 25 °C / pig liver esterase, pH 7.2

With sodium hydroxide; n-butyllithium; diisopropylamine; In water;
DOI:10.1021/jo00038a041

Reference yield:

: 127047-04-5
dimethyl 2-methyl-2-(4-methylphenyl)malonate

: 877077-49-1
(R)-(+)-2-(methoxycarbonyl)-2-(4-methylphenyl)propionic acid

: 127047-08-9
(S)-2-Methyl-2-p-tolyl-malonic acid monomethyl ester

Guidance literature:: With sodium hydroxide; at 21 ℃; for 53h; Yield given. Yields of byproduct given. Title compound not separated from byproducts; pig liver esterase (PLE);
DOI:10.1016/S0957-4166(00)86155-8