Azetidine, 3-methyl-1-[(4-methylphenyl)sulfonyl]-2-phenyl-, (2R,3R)-

Base Information

Chemical Name:Azetidine, 3-methyl-1-[(4-methylphenyl)sulfonyl]-2-phenyl-, (2R,3R)-
CAS No.:877081-04-4
Molecular Formula:C17H19NO2S
Molecular Weight:301.409
Hs Code.:

Synonyms:

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Chemical Property of Azetidine, 3-methyl-1-[(4-methylphenyl)sulfonyl]-2-phenyl-, (2R,3R)-

Chemical Property:

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Technology Process of Azetidine, 3-methyl-1-[(4-methylphenyl)sulfonyl]-2-phenyl-, (2R,3R)-

There total 4 articles about Azetidine, 3-methyl-1-[(4-methylphenyl)sulfonyl]-2-phenyl-, (2R,3R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 127598-09-8
N-(3-hydroxy-2-methyl-1-phenylpropyl)-4-methylbenzenesulfonamide

: 877081-04-4
(2R,3R)-3-methyl-2-phenyl-1-tosylazetidine

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 20 ℃; for 24h;
DOI:10.1021/ol100073y

Reference yield:

: (S)-2-Methyl-1-phenyl-3-(2-trimethylsilanyl-ethoxy)-propylamine

: 877081-04-4
(2R,3R)-3-methyl-2-phenyl-1-tosylazetidine

Guidance literature:: Multi-step reaction with 3 steps

1: K₂CO₃ / CH₂Cl₂ / 14 h

2: aq. LiBF₄ / acetonitrile / Heating

3: 661 mg / PPh₃; diisopropyl azodicarboxylate / tetrahydrofuran / 24 h / 20 °C

With lithium tetrafluoroborate; di-isopropyl azodicarboxylate; potassium carbonate; triphenylphosphine; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1055/s-2005-918421

Reference yield:

: ((R)-2-Methoxymethyl-pyrrolidin-1-yl)-[(S)-2-methyl-1-phenyl-3-(2-trimethylsilanyl-ethoxy)-propyl]-amine

: 877081-04-4
(2R,3R)-3-methyl-2-phenyl-1-tosylazetidine

Guidance literature:: Multi-step reaction with 4 steps

1: BH₃ / tetrahydrofuran / 4 h / Heating

2: K₂CO₃ / CH₂Cl₂ / 14 h

3: aq. LiBF₄ / acetonitrile / Heating

4: 661 mg / PPh₃; diisopropyl azodicarboxylate / tetrahydrofuran / 24 h / 20 °C

With lithium tetrafluoroborate; di-isopropyl azodicarboxylate; borane; potassium carbonate; triphenylphosphine; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1055/s-2005-918421