5-fluoro-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]pyrimidine-2,4-dione

Base Information

Chemical Name:5-fluoro-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]pyrimidine-2,4-dione
CAS No.:145986-11-4
Molecular Formula:C₈H₉FN₂O₄S
Molecular Weight:248.235
Hs Code.:
European Community (EC) Number:875-647-2
UNII:7D832RLM83
DSSTox Substance ID:DTXSID10932106
Nikkaji Number:J524.974K
Wikidata:Q82907768
ChEMBL ID:CHEMBL301450
Mol file:145986-11-4.mol

Synonyms:2',3',5-FTU;2',3'-dideoxy-5-fluoro-3'-thiauridine

Suppliers and Price of 5-fluoro-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]pyrimidine-2,4-dione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
cis5-Fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-2,4(1H,3H)-pyrimidinedione
100mg
$ 5375.00

AvaChem
5-Fluoro-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]uracil
10mg
$ 275.00

AvaChem
5-Fluoro-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]uracil
5mg
$ 175.00

AvaChem
5-Fluoro-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]uracil
25mg
$ 575.00

American Custom Chemicals Corporation
EMTRICITABINE RELATED COMPOUND 1 95.00%
5MG
$ 457.16

AK Scientific
cis5-Fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-2,4(1H,3H)-pyrimidinedione
100mg
$ 894.00

Total 13 raw suppliers

Chemical Property of 5-fluoro-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]pyrimidine-2,4-dione

Chemical Property:

Melting Point:192-194°C
Boiling Point:°Cat760mmHg
Flash Point:°C
PSA：109.62000
Density:1.65g/cm³
LogP:-0.74390
Storage Temp.:Hygroscopic, -20°C Freezer, Under Inert Atmosphere
Solubility.:DMSO (Slightly), Ethanol (Slightly, Heated), Methanol (Slightly)
XLogP3:-0.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:2
Exact Mass:248.02670611
Heavy Atom Count:16
Complexity:362

Purity/Quality:

99%, ^*data from raw suppliers

cis5-Fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-2,4(1H,3H)-pyrimidinedione ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1C(OC(S1)CO)N2C=C(C(=O)NC2=O)F
Isomeric SMILES:C1[C@H](O[C@H](S1)CO)N2C=C(C(=O)NC2=O)F
Uses Antiviral nucleoside analog, also an impurity found in emtricitabine (E525000).

Technology Process of 5-fluoro-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]pyrimidine-2,4-dione

There total 2 articles about 5-fluoro-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]pyrimidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.4%