METHYL 2-OXOVALERATE

Base Information

• Chemical Name: METHYL 2-OXOVALERATE
• CAS No.: 6376-59-6
• Molecular Formula: C6H10 O3
• Molecular Weight: 130.144
• Hs Code.: 2918300090
• Mol file: 6376-59-6.mol

Synonyms:Valeric acid,2-oxo-, methyl ester (7CI,8CI); Methyl 2-oxopentanoate; Methyl 2-oxovalerate;Methyl a-oxovalerate

Chemical Property of METHYL 2-OXOVALERATE

Chemical Property:

• Refractive Index: 1.4140-1.4180
• Boiling Point: 62 °C / 12mmHg
• PSA: 43.37000
• LogP: 0.52860
• Storage Temp.: 0-10°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

Methyl 2-Oxovalerate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of METHYL 2-OXOVALERATE

There total 13 articles about METHYL 2-OXOVALERATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

(Z)-2-Amino-pent-2-enoic acid ethyl ester (71385-54-1) → Methyl-2-oxopentanoate (6376-59-6)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; for 0.5h; Ambient temperature;

DOI:10.1248/cpb.32.3934

Reference yield: 95.0%

(Z)-2-Amino-pent-2-enoic acid methyl ester (95863-99-3) → Methyl-2-oxopentanoate (6376-59-6)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; for 0.5h; Ambient temperature;

DOI:10.1248/cpb.32.3934

Reference yield: 81.0%

Dimethyl oxalate (553-90-2) → Methyl-2-oxopentanoate (6376-59-6)

Guidance literature:

Dimethyl oxalate; propylmagnesium halide; In tetrahydrofuran; at -78 ℃; for 1h;

With hydrogenchloride; water; In tetrahydrofuran; at 10 ℃;

DOI:10.1021/acs.joc.5b00241

upstream raw materials:

diazomethane

2-oxopentanoic acid

methyl 2-cyclopropyl-2-oxoacetate

(Z)-2-Amino-pent-2-enoic acid ethyl ester

Downstream raw materials:

5-ethyl-2-methylthiazole-4-carboxylic acid

(-)-(3R,5S)-methyl 2-benzyl-5-formyl-5-methyl-3-propylisoxazolidine-3-carboxylate

(E)-N-(1-methoxy-1-oxopentan-2-ylidene)-1-phenylmethanamine oxide

2-oxopentanoic acid

Refernces

• 1、 Ece, Hamdiye,Tange, Yuji,Yurino, Taiga,Ohkuma, Takeshi. "Silyl Cyanopalladate-Catalyzed Friedel-Crafts-Type Cyclization Affording 3-Aryloxindole Derivatives". supporting information. p. 935 - 939. Retrieved 2021/02/22.
• 2、 Lin, Zechao,Li, Jiahong,Huang, Qingfei,Huang, Qiuya,Wang, Qiwei,Tang, Lei,Gong, Deying,Yang, Jun,Zhu, Jin,Deng, Jingen. "Chiral Surfactant-Type Catalyst: Enantioselective Reduction of Long-Chain Aliphatic Ketoesters in Water". . p. 4419 - 4429. Retrieved 2015/05/13.