Technology Process of F 050
There total 8 articles about F 050 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
palladium 10% on activated carbon; hydrogen;
In
ethanol;
at 30 ℃;
for 21h;
under 3040.2 Torr;
DOI:10.1002/anie.201106706
- Guidance literature:
-
Multi-step reaction with 4 steps
1: bis(tri-t-butylphosphine)palladium(0); water; caesium carbonate / 1,2-dimethoxyethane / 40.5 h / 80 °C
2: Iodine monochloride / dichloromethane / 2 h / 0 °C
3: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / tetrahydrofuran / 21 h / 20 °C
4: palladium 10% on activated carbon; hydrogen / ethanol / 21 h / 30 °C / 3040.2 Torr
With
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; bis(tri-t-butylphosphine)palladium(0); palladium 10% on activated carbon; water; hydrogen; Iodine monochloride; caesium carbonate; triethylamine;
In
tetrahydrofuran; 1,2-dimethoxyethane; ethanol; dichloromethane;
1: Suzuki coupling / 3: Sonogashira coupling;
DOI:10.1002/anie.201106706
- Guidance literature:
-
Multi-step reaction with 3 steps
1: Iodine monochloride / dichloromethane / 2 h / 0 °C
2: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / tetrahydrofuran / 21 h / 20 °C
3: palladium 10% on activated carbon; hydrogen / ethanol / 21 h / 30 °C / 3040.2 Torr
With
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; palladium 10% on activated carbon; hydrogen; Iodine monochloride; triethylamine;
In
tetrahydrofuran; ethanol; dichloromethane;
2: Sonogashira coupling;
DOI:10.1002/anie.201106706
