2(3H)-Furanone, 4-[2-(3,4-dimethoxyphenyl)-1,3-dithian-2-yl]-3-[[4-[[(1,1-dimethylethyl)di methylsilyl]oxy]-3-methoxyphenyl]methyl]dihydro-, (3R,4R)-

Base Information

Chemical Name:2(3H)-Furanone, 4-[2-(3,4-dimethoxyphenyl)-1,3-dithian-2-yl]-3-[[4-[[(1,1-dimethylethyl)di methylsilyl]oxy]-3-methoxyphenyl]methyl]dihydro-, (3R,4R)-
CAS No.:877438-68-1
Molecular Formula:C30H42O6S2Si
Molecular Weight:590.877
Hs Code.:

2(3H)-Furanone,
4-[2-(3,4-dimethoxyphenyl)-1,3-dithian-2-yl]-3-[[4-[[(1,1-dimethylethyl)di
methylsilyl]oxy]-3-methoxyphenyl]methyl]dihydro-, (3R,4R)-

Synonyms:

Suppliers and Price of 2(3H)-Furanone, 4-[2-(3,4-dimethoxyphenyl)-1,3-dithian-2-yl]-3-[[4-[[(1,1-dimethylethyl)di methylsilyl]oxy]-3-methoxyphenyl]methyl]dihydro-, (3R,4R)-

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2(3H)-Furanone, 4-[2-(3,4-dimethoxyphenyl)-1,3-dithian-2-yl]-3-[[4-[[(1,1-dimethylethyl)di methylsilyl]oxy]-3-methoxyphenyl]methyl]dihydro-, (3R,4R)-

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Technology Process of 2(3H)-Furanone, 4-[2-(3,4-dimethoxyphenyl)-1,3-dithian-2-yl]-3-[[4-[[(1,1-dimethylethyl)di methylsilyl]oxy]-3-methoxyphenyl]methyl]dihydro-, (3R,4R)-

There total 3 articles about 2(3H)-Furanone, 4-[2-(3,4-dimethoxyphenyl)-1,3-dithian-2-yl]-3-[[4-[[(1,1-dimethylethyl)di methylsilyl]oxy]-3-methoxyphenyl]methyl]dihydro-, (3R,4R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 877438-58-9
(3R)-3-[(propane-1,3-diyldithio)-(3,4-dimethoxyphenyl)methyl]butano-4-lactone

: 113931-97-8
4-<(tert-butyldimethylsilyl)oxy>-3-methoxybenzyl bromide

: 877438-68-1
(8R,8'R)-4-(tert-butyldimethylsilanyloxy)-3,3',4'-trimethoxy-7'-(propane-1,3-diyldithio)lignano-9,9'-lactone

Guidance literature:: (3R)-3-[(propane-1,3-diyldithio)-(3,4-dimethoxyphenyl)methyl]butano-4-lactone; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 2h;

4-<(tert-butyldimethylsilyl)oxy>-3-methoxybenzyl bromide; In tetrahydrofuran; at -78 - 20 ℃; Further stages.;
DOI:10.1039/b513303c

Reference yield:

: 877438-51-2
(3R,4R)-3-[(propane-1,3-diyldithio)-(3,4-dimethoxyphenyl)methyl]-4-[(1R,2S,5R)-2-(1-methylethyl)-5-methyl-1-cyclohexyloxy]butano-4-lactone

: 877438-68-1
(8R,8'R)-4-(tert-butyldimethylsilanyloxy)-3,3',4'-trimethoxy-7'-(propane-1,3-diyldithio)lignano-9,9'-lactone

Guidance literature:: Multi-step reaction with 2 steps

1.1: 60 percent / NaBH₄; KOH / ethanol / 3 h / 0 - 20 °C

2.1: LHMDS / tetrahydrofuran / 2 h / -78 °C

2.2: 78 percent / N,N-dimethyl-2-imidazolidinone / tetrahydrofuran / -78 - 20 °C

With potassium hydroxide; sodium tetrahydroborate; lithium hexamethyldisilazane; In tetrahydrofuran; ethanol;
DOI:10.1039/b513303c

Reference yield:

: 50766-67-1
2-(3,4-dimethoxyphenyl)-1,3-dithiane

: 877438-68-1
(8R,8'R)-4-(tert-butyldimethylsilanyloxy)-3,3',4'-trimethoxy-7'-(propane-1,3-diyldithio)lignano-9,9'-lactone

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-BuLi / tetrahydrofuran; hexane / 1 h / -78 °C

1.2: 82 percent / 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone / tetrahydrofuran; hexane / 2 h / -78 °C

2.1: 60 percent / NaBH₄; KOH / ethanol / 3 h / 0 - 20 °C

3.1: LHMDS / tetrahydrofuran / 2 h / -78 °C

3.2: 78 percent / N,N-dimethyl-2-imidazolidinone / tetrahydrofuran / -78 - 20 °C

With potassium hydroxide; sodium tetrahydroborate; n-butyllithium; lithium hexamethyldisilazane; In tetrahydrofuran; ethanol; hexane; 1.2: Michael addition;
DOI:10.1039/b513303c