9H-Purin-6-amine, 9-[(2R,3R)-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-5-[[[(1,1-dimethylethyl )dimethylsilyl]oxy]methyl]-2,3-dihydro-2-furanyl]-

Base Information

• Chemical Name: 9H-Purin-6-amine, 9-[(2R,3R)-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-5-[[[(1,1-dimethylethyl )dimethylsilyl]oxy]methyl]-2,3-dihydro-2-furanyl]-
• CAS No.: 877465-92-4
• Molecular Formula: C22H39N5O3Si2
• Molecular Weight: 477.754
• Mol file: 877465-92-4.mol

Synonyms:

Chemical Property of 9H-Purin-6-amine, 9-[(2R,3R)-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-5-[[[(1,1-dimethylethyl )dimethylsilyl]oxy]methyl]-2,3-dihydro-2-furanyl]-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 9H-Purin-6-amine, 9-[(2R,3R)-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-5-[[[(1,1-dimethylethyl )dimethylsilyl]oxy]methyl]-2,3-dihydro-2-furanyl]-

There total 1 articles about 9H-Purin-6-amine, 9-[(2R,3R)-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-5-[[[(1,1-dimethylethyl )dimethylsilyl]oxy]methyl]-2,3-dihydro-2-furanyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

C29H44IN5O5Si2 (1018978-93-2) → 9-[2,5-bis-O-(tert-butyldimethylsilyl)-3-deoxy-β-D-glyceropent-3-enofuranosyl]adenine (877465-92-4) + C29H45N5O5Si2 (1018978-94-3)

Guidance literature:

With hydrogen; triethylamine; palladium on activated charcoal; In methanol;

DOI:10.1016/j.tet.2008.01.018

Reference yield: 64.0%

9-[2,5-bis-O-(tert-butyldimethylsilyl)-3-deoxy-β-D-glyceropent-3-enofuranosyl]adenine (877465-92-4) + benzoic acid (65-85-0,8013-63-6) → 9-[4-benzoyloxy-2,5-bis-O-(tert-butyldimethylsilyl)-3-deoxy-3-iodo-α-L-lyxofuranosyl]adenine (1016648-21-7)

Guidance literature:

With dmap; N-iodo-succinimide; In dichloromethane; at 20 ℃; for 3.5h;

DOI:10.1016/j.tet.2008.01.018

Reference yield:

9-[2,5-bis-O-(tert-butyldimethylsilyl)-3-deoxy-β-D-glyceropent-3-enofuranosyl]adenine (877465-92-4) + benzoic acid (65-85-0,8013-63-6) → 4'-benzoyloxy-2',5'-bis-O-(tert-butyldimethylsilyl)-3'-deoxy-3'-iodoadenosine (1016648-20-6) + 9-[4-benzoyloxy-2,5-bis-O-(tert-butyldimethylsilyl)-3-deoxy-3-iodo-α-L-lyxofuranosyl]adenine (1016648-21-7)

Guidance literature:

With N-iodo-succinimide; In dichloromethane; at 20 ℃; for 3h;

DOI:10.1016/j.tet.2008.01.018

upstream raw materials:

C₂₉H₄₄IN₅O₅Si₂

Downstream raw materials:

4'-benzoyloxy-2',5'-bis-O-(tert-butyldimethylsilyl)-3'-deoxy-3'-iodoadenosine

9-[4-benzoyloxy-2,5-bis-O-(tert-butyldimethylsilyl)-3-deoxy-3-iodo-α-L-lyxofuranosyl]adenine

2',5'-bis-O-(tert-butyldimethylsilyl)-4'-phenylsulfanylcordycepin

9-[2,5-bis-O-(tert-butyldimethylsilyl)-3-deoxy-4-phenylsulfanyl-α-L-lyxofuranosyl]adenine