Technology Process of Cyclohexanecarboxylic acid,
3-(1,1-dimethyl-4-oxobutyl)-1,2-dimethyl-5-oxo-, methyl ester,
(1R,2R,3S)-
There total 8 articles about Cyclohexanecarboxylic acid,
3-(1,1-dimethyl-4-oxobutyl)-1,2-dimethyl-5-oxo-, methyl ester,
(1R,2R,3S)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(1R,2R,3S)-3-(1,1-Dimethyl-pent-4-enyl)-1,2-dimethyl-5-oxo-cyclohexanecarboxylic acid methyl ester;
With
ozone;
In
dichloromethane;
at -78 ℃;
for 0.333333h;
With
dimethylsulfide;
at -78 - 20 ℃;
DOI:10.1021/ja057483x
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: Jones' reagent / acetone / 1 h / 0 °C
2.1: aq. NaHCO3; KI; I2 / tetrahydrofuran / 6 h / 0 °C
3.1: DBU / tetrahydrofuran / 12 h / Heating
4.1: methanol / 3 h / 20 °C
5.1: pyridinium chlorochromate / CH2Cl2 / 1 h / 20 °C
6.1: lithium di-tert-butyl-biphenylide / tetrahydrofuran / 0.17 h / -78 °C
6.2: CuCN / tetrahydrofuran / 1 h / -78 °C
6.3: Me3SiCl / tetrahydrofuran / 1 h / -78 °C
7.1: O3 / CH2Cl2 / 0.33 h / -78 °C
7.2: dimethyl sulfide / -78 - 20 °C
With
jones' reagent; lithium di-tert-butyl-biphenylide; iodine; sodium hydrogencarbonate; ozone; 1,8-diazabicyclo[5.4.0]undec-7-ene; pyridinium chlorochromate; potassium iodide;
In
tetrahydrofuran; methanol; dichloromethane; acetone;
DOI:10.1021/ja057483x
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: methanol / 3 h / 20 °C
2.1: pyridinium chlorochromate / CH2Cl2 / 1 h / 20 °C
3.1: lithium di-tert-butyl-biphenylide / tetrahydrofuran / 0.17 h / -78 °C
3.2: CuCN / tetrahydrofuran / 1 h / -78 °C
3.3: Me3SiCl / tetrahydrofuran / 1 h / -78 °C
4.1: O3 / CH2Cl2 / 0.33 h / -78 °C
4.2: dimethyl sulfide / -78 - 20 °C
With
lithium di-tert-butyl-biphenylide; ozone; pyridinium chlorochromate;
In
tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/ja057483x
