Cyclobutanecarboxylic acid, 2,3-diacetyl-4-[[(phenylmethyl)amino]carbonyl]-, 1-methylethyl ester, (1S,2R,3S,4S)-

Base Information

• Chemical Name: Cyclobutanecarboxylic acid, 2,3-diacetyl-4-[[(phenylmethyl)amino]carbonyl]-, 1-methylethyl ester, (1S,2R,3S,4S)-
• CAS No.: 877822-60-1
• Molecular Formula: C20H25NO5
• Molecular Weight: 359.422
• Mol file: 877822-60-1.mol

Synonyms:

Chemical Property of Cyclobutanecarboxylic acid, 2,3-diacetyl-4-[[(phenylmethyl)amino]carbonyl]-, 1-methylethyl ester, (1S,2R,3S,4S)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Cyclobutanecarboxylic acid, 2,3-diacetyl-4-[[(phenylmethyl)amino]carbonyl]-, 1-methylethyl ester, (1S,2R,3S,4S)-

There total 1 articles about Cyclobutanecarboxylic acid, 2,3-diacetyl-4-[[(phenylmethyl)amino]carbonyl]-, 1-methylethyl ester, (1S,2R,3S,4S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(1R,4S)-3-Benzylcarbamoyl-1,4-dimethyl-7-oxa-bicyclo[2.2.1]hepta-2,5-diene-2-carboxylic acid isopropyl ester (877822-59-8) → (1S,2R,3S,4S)-2,3-Diacetyl-4-benzylcarbamoyl-cyclobutanecarboxylic acid isopropyl ester (877822-60-1)

Guidance literature:

(1R,4S)-3-Benzylcarbamoyl-1,4-dimethyl-7-oxa-bicyclo[2.2.1]hepta-2,5-diene-2-carboxylic acid isopropyl ester; In tetrahydrofuran; for 72h; UV-irradiation;

With sulfuric acid; In tetrahydrofuran; methanol; at 20 ℃; for 3h;

DOI:10.1021/ja069035a

Reference yield:

(1S,2R,3S,4S)-2,3-Diacetyl-4-benzylcarbamoyl-cyclobutanecarboxylic acid isopropyl ester (877822-60-1) → 3,4-bis-(3,3,3-trifluoro-2-methoxy-2-phenyl-propionyloxymethyl)-cyclobutane-1,2-dicarboxylic acid dimethyl ester

Guidance literature:

Multi-step reaction with 2 steps

1.1: 90 percent / p-toluenesulfonic acid / toluene / 12 h / 105 °C

2.2: pyridine

With toluene-4-sulfonic acid; In toluene;

DOI:10.1021/ja069035a

Reference yield:

(1S,2R,3S,4S)-2,3-Diacetyl-4-benzylcarbamoyl-cyclobutanecarboxylic acid isopropyl ester (877822-60-1) → 3,4-bis-(3,3,3-trifluoro-2-methoxy-2-phenyl-propionyloxymethyl)-cyclobutane-1,2-dicarboxylic acid dimethyl ester

Guidance literature:

Multi-step reaction with 2 steps

1.1: 90 percent / p-toluenesulfonic acid / toluene / 12 h / 105 °C

2.2: pyridine

With toluene-4-sulfonic acid; In toluene;

DOI:10.1021/ja069035a

upstream raw materials:

(1R,4S)-3-Benzylcarbamoyl-1,4-dimethyl-7-oxa-bicyclo[2.2.1]hepta-2,5-diene-2-carboxylic acid isopropyl ester