2,4-Thiazolidinedione, 5-[[4-[(4-hydroxy-1-methylcyclohexyl)methoxy]phenyl]methyl]-, trans-

Base Information

Chemical Name:2,4-Thiazolidinedione, 5-[[4-[(4-hydroxy-1-methylcyclohexyl)methoxy]phenyl]methyl]-, trans-
CAS No.:87787-45-9
Molecular Formula:C18H23NO4S
Molecular Weight:349.451
Hs Code.:

Synonyms:

Suppliers and Price of 2,4-Thiazolidinedione, 5-[[4-[(4-hydroxy-1-methylcyclohexyl)methoxy]phenyl]methyl]-, trans-

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2,4-Thiazolidinedione, 5-[[4-[(4-hydroxy-1-methylcyclohexyl)methoxy]phenyl]methyl]-, trans-

Chemical Property:

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Technology Process of 2,4-Thiazolidinedione, 5-[[4-[(4-hydroxy-1-methylcyclohexyl)methoxy]phenyl]methyl]-, trans-

There total 9 articles about 2,4-Thiazolidinedione, 5-[[4-[(4-hydroxy-1-methylcyclohexyl)methoxy]phenyl]methyl]-, trans- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.6%

: 93392-63-3
5-<4-(t-4-hydroxy-1-methyl-r-1-cyclohexylmethoxy)benzyl>-2-imino-4-thiazolidinone

: 87787-45-9
5-<4-(t-4-hydroxy-1-methyl-r-1-cyclohexylmethoxy)benzyl>-2,4-thiazolidinedione

Guidance literature:: With hydrogenchloride; In ethanol; for 24h; Heating;
DOI:10.1248/cpb.32.2267

Reference yield:

: 6493-80-7,357418-50-9
methyl 1-methyl-3-cyclohexenecarboxylate

: 87787-45-9
5-<4-(t-4-hydroxy-1-methyl-r-1-cyclohexylmethoxy)benzyl>-2,4-thiazolidinedione

Guidance literature:: Multi-step reaction with 9 steps

1: 1.) Hg(OAc)2; 2.) 3N NaOH, NaBH₄ / 1.) THF-H₂O, RT, 30 min; 2.) RT

2: p-TsOH / diethyl ether / Ambient temperature

3: LiAlH₄ / diethyl ether / Ambient temperature

4: NaH / dimethylsulfoxide / 3 h / 30 °C

5: 2N HCl / methanol / 1 h / Ambient temperature

6: H₂ / Pd-C / methanol / 760 Torr / Ambient temperature

7: 1.) 47percent HBr, NaNO₂; 2.) Cu₂O / 1.) acetone, water, 5 deg C, 30 min; 2.) 35 deg C

8: 60.5 percent / NaOAc / ethanol / 3 h / Heating

9: 98.6 percent / 2N HCl / ethanol / 24 h / Heating

With copper(I) oxide; hydrogenchloride; sodium hydroxide; sodium tetrahydroborate; lithium aluminium tetrahydride; mercury(II) diacetate; hydrogen bromide; hydrogen; sodium acetate; sodium hydride; toluene-4-sulfonic acid; sodium nitrite; palladium on activated charcoal; In methanol; diethyl ether; ethanol; dimethyl sulfoxide;
DOI:10.1248/cpb.32.2267

Reference yield:

: 87787-12-0
1-methyl-t-4-(2-tetrahydropyranyloxy)-r-1-cyclohexanemethanol

: 87787-45-9
5-<4-(t-4-hydroxy-1-methyl-r-1-cyclohexylmethoxy)benzyl>-2,4-thiazolidinedione

Guidance literature:: Multi-step reaction with 6 steps

1: NaH / dimethylsulfoxide / 3 h / 30 °C

2: 2N HCl / methanol / 1 h / Ambient temperature

3: H₂ / Pd-C / methanol / 760 Torr / Ambient temperature

4: 1.) 47percent HBr, NaNO₂; 2.) Cu₂O / 1.) acetone, water, 5 deg C, 30 min; 2.) 35 deg C

5: 60.5 percent / NaOAc / ethanol / 3 h / Heating

6: 98.6 percent / 2N HCl / ethanol / 24 h / Heating

With copper(I) oxide; hydrogenchloride; hydrogen bromide; hydrogen; sodium acetate; sodium hydride; sodium nitrite; palladium on activated charcoal; In methanol; ethanol; dimethyl sulfoxide;
DOI:10.1248/cpb.32.2267