4-Azidobiphenyl

Base Information

• Chemical Name: 4-Azidobiphenyl
• CAS No.: 31656-91-4
• Molecular Formula: C12H9 N3
• Molecular Weight: 195.224
• Hs Code.: 2929909090
• UNII: CVA737WG4E
• DSSTox Substance ID: DTXSID00185548
• Nikkaji Number: J102.141I
• Wikidata: Q27275843
• Mol file: 31656-91-4.mol

Synonyms:4-azido-1,1'-biphenyl;4-azidobiphenyl

Chemical Property of 4-Azidobiphenyl

Chemical Property:

• Melting Point: 77-79 °C
• PSA: 49.75000
• LogP: 3.74816
• XLogP3: 4.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 195.079647300
• Heavy Atom Count: 15
• Complexity: 231

Purity/Quality:

1-Azido-4-phenylbenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C2=CC=C(C=C2)N=[N+]=[N-]

Technology Process of 4-Azidobiphenyl

There total 15 articles about 4-Azidobiphenyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-biphenyldiazonium tetrafluoroborate → 4-azidobiphenyl (31656-91-4)

Guidance literature:

With trimethylsilylazide; In N,N-dimethyl-formamide; for 1h; Ambient temperature;

DOI:10.1246/bcsj.62.89

Reference yield: 96.0%

2-(biphenyl-4-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (144432-80-4) → 4-azidobiphenyl (31656-91-4)

Guidance literature:

With trimethylsilylazide; tetrabutyl ammonium fluoride; copper(l) chloride; In tetrahydrofuran; methanol; for 8h; Reflux; In air;

DOI:10.1002/chem.201000971

Reference yield: 95.0%

4-phenylalanine (92-67-1) → 4-azidobiphenyl (31656-91-4)

Guidance literature:

4-phenylalanine; With tert.-butylnitrite; boron trifluoride diethyl etherate; In tetrahydrofuran; at -15 - 5 ℃; for 1.5h;

With sodium azide; In water; acetonitrile; at 75 ℃;

DOI:10.1021/ja312303a

upstream raw materials:

4-phenylalanine

4-bromo-aniline

phenylboronic acid

2-(biphenyl-4-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Downstream raw materials:

biphenyl-4-yl-triphenylphosphoranyliden-amine

4-Methoxy-4'-phenyl-azobenzol

1,2-di([1,1'-biphenyl]-4-yl)diazene

4-phenylalanine