Bis(2-chloroethyl)ethylamine

Base Information

Chemical Name:Bis(2-chloroethyl)ethylamine
CAS No.:538-07-8
Molecular Formula:C6H13 Cl2 N
Molecular Weight:170.082
Hs Code.:2921193000
ICSC Number:1655
UN Number:2810
UNII:B75ZZA7WIG
DSSTox Substance ID:DTXSID0060220
Nikkaji Number:J6.367C
Wikipedia:HN1_(nitrogen_mustard)
Wikidata:Q5635296
Mol file:538-07-8.mol

Synonyms:bis(2-chloroethyl)ethylamine;HN-1 cpd

Suppliers and Price of Bis(2-chloroethyl)ethylamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
BIS(2-CHLOROETHYL)ETHYLAMINE 95.00%
5MG
$ 498.83

Total 8 raw suppliers

Chemical Property of Bis(2-chloroethyl)ethylamine

Chemical Property:

Vapor Pressure:7.63mmHg at 25°C
Melting Point:-33.9°C
Refractive Index:1.6000 (estimate)
Boiling Point:135.7°C at 760 mmHg
PKA:6.48±0.50(Predicted)
Flash Point:35.9°C
PSA：3.24000
Density:1.079g/cm³
LogP:1.78590
XLogP3:1.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:5
Exact Mass:169.0425048
Heavy Atom Count:9
Complexity:53

Purity/Quality:

98%min ^*data from raw suppliers

BIS(2-CHLOROETHYL)ETHYLAMINE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Chemical Classes:Toxic Gases & Vapors -> Chemical Weapons
Canonical SMILES:CCN(CCCl)CCCl
Inhalation Risk:A harmful contamination of the air will be reached quickly on evaporation of this substance at 20 °C; on spraying or dispersing, however, much faster.
Effects of Short Term Exposure:Blistering agent. Lachrymation. The substance is severely irritating to the eyes, skin and respiratory tract. The substance may cause effects on the central nervous system and bone marrow. Inhalation may cause lung oedema. The effects may be delayed. Medical observation is indicated.
Effects of Long Term Exposure:The substance may have effects on the bone marrow and central nervous system. This substance is probably carcinogenic to humans. May cause heritable genetic damage to human germ cells.
Uses Although nitrogen mustards could be used in chemical warfare, there are presently no records of such use. HN-1 has been used to remove warts in the past, Nitrogen mustards are among the blister agents/vesicants used in chemical warfare. HN-1 was originally designed to remove warts and later identified as a potential chemical warfare agent. HN-2 was designed as a military agent, but later used in cancer chemotherapy. HN-3 was developed as a military chemical warfare agent. Nitrogen mustards have also found therapeutic applications in cancer treatment, and there are several pharmaceutical derivatives that were developed as cancer therapeutic agents.

Technology Process of Bis(2-chloroethyl)ethylamine

There total 2 articles about Bis(2-chloroethyl)ethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 139-87-7
ethyldiethanolamine

: 538-07-8
bis(2-chloroethyl)(ethyl)amine

Guidance literature:: ethyldiethanolamine; With thionyl chloride; In dichloromethane; at 0 - 20 ℃; for 20h;

With sodium hydrogencarbonate; In dichloromethane; water; pH=7;

Reference yield:

: 19945-22-3
N,N-bis-(2-chloro-ethyl)-acetamide

: 538-07-8
bis(2-chloroethyl)(ethyl)amine

Guidance literature:: With lithium aluminium tetrahydride; In diethyl ether; Ambient temperature;

Reference yield: 86.0%

: 538-07-8
bis(2-chloroethyl)(ethyl)amine

: C₂₂H₂₂BrNO

: C₅₀H₅₅Br₂N₃O₂

Guidance literature:: C₂₂H₂₂BrNO; With sodium hydride; In 1,4-dioxane; at 20 ℃; for 0.5h;

bis(2-chloroethyl)(ethyl)amine; In 1,4-dioxane; at 110 ℃; for 1h;
DOI:10.1016/j.dyepig.2020.108985