1-Piperidinecarboxylic acid, 2-[(1S,2S)-2-[bis(phenylmethyl)amino]-3-(3,5-difluorophenyl)-1-hydroxy propyl]-, 1,1-dimethylethyl ester, (2R)-

Base Information

Chemical Name:1-Piperidinecarboxylic acid, 2-[(1S,2S)-2-[bis(phenylmethyl)amino]-3-(3,5-difluorophenyl)-1-hydroxy propyl]-, 1,1-dimethylethyl ester, (2R)-
CAS No.:878137-93-0
Molecular Formula:C33H40F2N2O3
Molecular Weight:550.689
Hs Code.:

1-Piperidinecarboxylic acid,
2-[(1S,2S)-2-[bis(phenylmethyl)amino]-3-(3,5-difluorophenyl)-1-hydroxy
propyl]-, 1,1-dimethylethyl ester, (2R)-

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-Piperidinecarboxylic acid, 2-[(1S,2S)-2-[bis(phenylmethyl)amino]-3-(3,5-difluorophenyl)-1-hydroxy propyl]-, 1,1-dimethylethyl ester, (2R)-

Chemical Property:

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Technology Process of 1-Piperidinecarboxylic acid, 2-[(1S,2S)-2-[bis(phenylmethyl)amino]-3-(3,5-difluorophenyl)-1-hydroxy propyl]-, 1,1-dimethylethyl ester, (2R)-

There total 1 articles about 1-Piperidinecarboxylic acid, 2-[(1S,2S)-2-[bis(phenylmethyl)amino]-3-(3,5-difluorophenyl)-1-hydroxy propyl]-, 1,1-dimethylethyl ester, (2R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 5.3%

: 845543-61-5
(S)-N,N-dibenzyl-3,5-difluorophenyl-alaninal

: 75844-69-8
t-butyl piperidinecarboxylate

: 878137-95-2
1-[1-(benzyl-cyclohexa-1,3-dienylmethyl-amino)-2-(3,5-difluoro-phenyl)-ethyl]-hexahydro-oxazolo[3,4-a]pyridin-3-one

: 878137-93-0
2-[2-(benzyl-cyclohexa-1,3-dienylmethyl-amino)-3-(3,5-difluoro-phenyl)-1-hydroxy-propyl]-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: t-butyl piperidinecarboxylate; With N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; In diethyl ether; cyclohexane; at -78 - -20 ℃; for 3.16667h;

(S)-N,N-dibenzyl-3,5-difluorophenyl-alaninal; In diethyl ether; cyclohexane; at -78 - 0 ℃;