5-BROMOIMIDAZO[1,2-A]PYRIDINE-2-CARBALDEHYDE

Base Information

• Chemical Name: 5-BROMOIMIDAZO[1,2-A]PYRIDINE-2-CARBALDEHYDE
• CAS No.: 878197-68-3
• Molecular Formula: C8H5BrN2O
• Molecular Weight: 225.04200
• Hs Code.: 2933990090
• Mol file: 878197-68-3.mol

Synonyms:5-BROMOIMIDAZO[1,2-A]PYRIDINE-2-CARBOXALDEHYDE;5-Bromo-imidazo[1,2-a]pyridine-2-carbaldehyde;QC-8490;

Chemical Property of 5-BROMOIMIDAZO[1,2-A]PYRIDINE-2-CARBALDEHYDE

Chemical Property:

• PKA: 1.70±0.50(Predicted)
• PSA: 34.37000
• Density: 1.73±0.1 g/cm3(Predicted)
• LogP: 1.90930
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

5-Bromoimidazo[1,2-a]pyridine-2-carbaldehyde 97.0% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-BROMOIMIDAZO[1,2-A]PYRIDINE-2-CARBALDEHYDE

There total 3 articles about 5-BROMOIMIDAZO[1,2-A]PYRIDINE-2-CARBALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

1,1,3-trichloroacetone (921-03-9) + C5H7BrN2 → 5-bromoimidazo[1,2-a]pyridine-2-carbaldehyde (878197-68-3)

Guidance literature:

With hydrogenchloride; In 1,2-dimethoxyethane; water; at 10 - 75 ℃;

Reference yield: 72.0%

2-Amino-6-bromopyridine (19798-81-3,1184170-10-2) + 1,1,3-trichloroacetone (921-03-9) → 5-bromoimidazo[1,2-a]pyridine-2-carbaldehyde (878197-68-3)

Guidance literature:

2-Amino-6-bromopyridine; 1,1,3-trichloroacetone; In 1,2-dimethoxyethane; at 25 - 65 ℃; Inert atmosphere; Large scale reaction;

With hydrogenchloride; In 1,2-dimethoxyethane; water; at 75 ℃; Large scale reaction;

With sodium hydroxide; In 1,2-dimethoxyethane; at 10 ℃; pH=8; Large scale reaction;

DOI:10.1021/op9000675

Reference yield:

C8H5BrCl2N2 → 5-bromoimidazo[1,2-a]pyridine-2-carbaldehyde (878197-68-3)

Guidance literature:

C₈H₅BrCl₂N₂; With hydrogenchloride; water; In 1,2-dimethoxyethane; at 75 ℃; for 16 - 20h;

With sodium hydroxide; water; In 1,2-dimethoxyethane; at 10 ℃; pH=~ 8;

upstream raw materials:

2-Amino-6-bromopyridine

1,1,3-trichloroacetone

Downstream raw materials:

5-(4-methyl-1-piperazinyl)imidazo[1,2-a]pyridine-2-carbaldehyde

(5-bromoimidazo[1,2-a]pyridin-2-yl)methanol

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