Trasylol

Base Information

• Chemical Name: Trasylol
• CAS No.: 57285-09-3
• Molecular Formula: C10H14N5O7P
• Molecular Weight: 347.221221
• European Community (EC) Number: 232-906-9,232-994-9
• NCI Thesaurus Code: C47402
• RXCUI: 1056
• Wikipedia: Aprotinin
• Mol file: 57285-09-3.mol

Synonyms:Antilysin;Aprotinin;Basic Pancreatic Trypsin Inhibitor;Bovine Kunitz Pancreatic Trypsin Inhibitor;Bovine Pancreatic Trypsin Inhibitor;BPTI, Basic Pancreatic Trypsin Inhibitor;Contrical;Contrykal;Dilmintal;Inactivator, Kallikrein-Trypsin;Iniprol;Kallikrein Trypsin Inactivator;Kallikrein-Trypsin Inactivator;Kontrikal;Kontrykal;Kunitz Pancreatic Trypsin Inhibitor;Pulmin;Traskolan;Trasylol;Trypsin Inhibitor, Basic, Pancreatic;Trypsin Inhibitor, Kunitz, Pancreatic;Zymofren

Chemical Property of Trasylol

Chemical Property:

• Storage Temp.: −20°C
• XLogP3: -25.4
• Hydrogen Bond Donor Count: 93
• Hydrogen Bond Acceptor Count: 97
• Rotatable Bond Count: 111
• Exact Mass: 6510.0514478
• Heavy Atom Count: 454
• Complexity: 16700

Purity/Quality:

99% ^*data from raw suppliers

Inhibin from porcine ovary lyophilized powder ^*data from reagent suppliers

Safty Information:

• Hazard Codes: T
• Statements: 60
• Safety Statements: 53-36/37/39-45

MSDS Files:

Useful:

• Canonical SMILES: CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NCC(=O)NC(C(=O)NC2CSSCC3C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)NC(C(=O)N4CCCC4C(=O)N5CCCC5C(=O)NC(C(=O)NC(C(=O)NCC(=O)N6CCCC6C(=O)NC(CSSCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N3)CC(=O)O)CCC(=O)O)C)CO)CCCCN)CC7=CC=CC=C7)CC(=O)N)CC(=O)N)CCCNC(=N)N)CCCCN)C)CCCNC(=N)N)NC(=O)CNC(=O)CNC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC2=O)CCC(=O)N)C(C)O)CC8=CC=CC=C8)C(C)C)CC9=CC=C(C=C9)O)C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CCCNC(=N)N)C)CCCCN)C(C)O)CC1=CC=C(C=C1)O)CCC(=O)O)CC(C)C)NC(=O)C(CC1=CC=CC=C1)NC(=O)C(CC(=O)O)NC(=O)C1CCCN1C(=O)C(CCCNC(=N)N)N)C(=O)NCC(=O)NCC(=O)NC(C)C(=O)O)C(C)O)CCCNC(=N)N)CCSC)CC(C)C)C)CCCCN)C)CC(=O)N)CC1=CC=C(C=C1)O)CC1=CC=CC=C1)CC1=CC=C(C=C1)O)CCCNC(=N)N)C(C)CC
• Isomeric SMILES: CC[C@H](C)[C@H]1C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@H]2CSSC[C@H]3C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N4CCC[C@H]4C(=O)N5CCC[C@H]5C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)N6CCC[C@H]6C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N3)CC(=O)O)CCC(=O)O)C)CO)CCCCN)CC7=CC=CC=C7)CC(=O)N)CC(=O)N)CCCNC(=N)N)CCCCN)C)CCCNC(=N)N)NC(=O)CNC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC2=O)CCC(=O)N)[C@@H](C)O)CC8=CC=CC=C8)C(C)C)CC9=CC=C(C=C9)O)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CCCNC(=N)N)C)CCCCN)[C@@H](C)O)CC1=CC=C(C=C1)O)CCC(=O)O)CC(C)C)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)N)C(=O)NCC(=O)NCC(=O)N[C@@H](C)C(=O)O)[C@@H](C)O)CCCNC(=N)N)CCSC)CC(C)C)C)CCCCN)C)CC(=O)N)CC1=CC=C(C=C1)O)CC1=CC=CC=C1)CC1=CC=C(C=C1)O)CCCNC(=N)N)[C@@H](C)CC
• Recent ClinicalTrials: An Open Non-comparative Study of the Efficacy and Safety of Aprotinin in Patients Hospitalized With COVID-19
• Recent EU Clinical Trials: Phase 3 randomized study to evaluate the safety and efficacy of aprotinin (Trasylol?) administered by inhalation nebulization in patients diagnosed with SARS-CoV-2 (COVID-19) with moderate severity compared to standard therapy.
• Biological functions: Inhibins suppress the expression of the FSH β-subunit in the pituitary, and thereby regulate gonadal functions and development. In addition, inhibins have paracrine and autocrine effects in various cells.?Inhibin α-subunit gene knockout mice develop Sertoli cell tumors in males and granulosa cell tumors in females. When the knockout mice were gonadectomized, the life expectancy increased; however, these mice developed adrenal tumors around 30 weeks of age. Inhibin βA-subunit gene knockout mice die perinatally and have defects in tooth, palate, and retinal formation.
• Description: Inhibin is a glycoprotein, a member of the transforming growth factor (TGF)-β superfamily. Inhibin is secreted mainly from the gonads and inhibits follicle-stimulating hormone (FSH) secretion from the anterior pituitary and in turn regulates gonadal function and development. The presence of FSH-inhibiting activity had been reported in the gonads since the 1970s, and the FSHinhibiting factor “inhibin” was first isolated in 1985 from porcine1 and bovine follicular fluid.
• Clinical Use: Inhibin levels in the circulation are a reliable marker for granulosa cell tumors and serous and mucinous epithelial carcinomas. This may be true for granulosa cell tumors in mares. Evaluation of plasma inhibin A levels until the second trimester of pregnancy is useful for screening for Down’s syndrome. The circulating inhibin B is a good predictor for the conditions of spermatogenesis. High levels of inhibin are noted in humans, rats, and dogs with Leydig cell tumors, whereas a low level clinically suggests a premature ovarian failure.

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