Chemical Property of 1,3-bis(4-Bromophenyl)-5-phenyl-2,4-imidazolidinedione
Chemical Property:
- PSA：40.62000
- LogP:6.05610
- XLogP3:5.5
- Hydrogen Bond Donor Count:0
- Hydrogen Bond Acceptor Count:2
- Rotatable Bond Count:3
- Exact Mass:485.94015
- Heavy Atom Count:27
- Complexity:550
- Purity/Quality:
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99% *data from raw suppliers
1,3-Bis(4-bromophenyl)-5-phenyl-2,4-imidazolidinedione *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:C1=CC=C(C=C1)C2C(=O)N(C(=O)N2C3=CC=C(C=C3)Br)C4=CC=C(C=C4)Br
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Description
Central cannabinoid (CB1) receptor antagonists and inverse agonists exhibit therapeutic potential for obesity and drug dependence, while being devoid of psychotropic effects. CAY10508 is a potent and selective central cannabinoid (CB1) receptor inverse agonist with a Ki value of 243 nM and an EC50 of 195 nM. A 10 μM concentration of CAY10508 resulted in 100% and 35% displacement of [3H]-CP-55,940 at the CB1 and peripheral cannabinoid (CB2) receptors, respectively. A [35S]-GTPγS binding assay revealed the inverse agonist properties of CAY10508 at the CB1 receptor.
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Uses
1,3-Bis(4-bromophenyl)-5-phenyl-2,4-imidazolidinedione is a central cannabinoid (CB1) receptor antagonist and inverse agonist. It may be a potential therapeutic agent for treating obesity and drug dependence. An imidazolidine-2,-4-dione derivative that is an effective and selective inverse agonist of CB cannabinoid receptor
