1,2-Pyrrolidinedicarboxylic acid, 1-(1,1-dimethylethyl) 2-[(1S,3R,5S,6S)-1-(1,1-dimethylethyl)-5-[[(1,1-dimethylethyl)dimethylsil yl]oxy]-3,6-dimethyl-7-[[(1S,2E)-3-methyl-4-oxo-4-(2-propenyloxy)-1-[[(tri phenylmethyl)thio]methyl]-2-butenyl]amino]-7-oxoheptyl] ester, (2S)-

Base Information

Chemical Name:1,2-Pyrrolidinedicarboxylic acid, 1-(1,1-dimethylethyl) 2-[(1S,3R,5S,6S)-1-(1,1-dimethylethyl)-5-[[(1,1-dimethylethyl)dimethylsil yl]oxy]-3,6-dimethyl-7-[[(1S,2E)-3-methyl-4-oxo-4-(2-propenyloxy)-1-[[(tri phenylmethyl)thio]methyl]-2-butenyl]amino]-7-oxoheptyl] ester, (2S)-
CAS No.:878626-80-3
Molecular Formula:C57H82N2O8SSi
Molecular Weight:983.438
Hs Code.:

1,2-Pyrrolidinedicarboxylic acid, 1-(1,1-dimethylethyl)
2-[(1S,3R,5S,6S)-1-(1,1-dimethylethyl)-5-[[(1,1-dimethylethyl)dimethylsil
yl]oxy]-3,6-dimethyl-7-[[(1S,2E)-3-methyl-4-oxo-4-(2-propenyloxy)-1-[[(tri
phenylmethyl)thio]methyl]-2-butenyl]amino]-7-oxoheptyl] ester, (2S)-

Synonyms:

Suppliers and Price of 1,2-Pyrrolidinedicarboxylic acid, 1-(1,1-dimethylethyl) 2-[(1S,3R,5S,6S)-1-(1,1-dimethylethyl)-5-[[(1,1-dimethylethyl)dimethylsil yl]oxy]-3,6-dimethyl-7-[[(1S,2E)-3-methyl-4-oxo-4-(2-propenyloxy)-1-[[(tri phenylmethyl)thio]methyl]-2-butenyl]amino]-7-oxoheptyl] ester, (2S)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1,2-Pyrrolidinedicarboxylic acid, 1-(1,1-dimethylethyl) 2-[(1S,3R,5S,6S)-1-(1,1-dimethylethyl)-5-[[(1,1-dimethylethyl)dimethylsil yl]oxy]-3,6-dimethyl-7-[[(1S,2E)-3-methyl-4-oxo-4-(2-propenyloxy)-1-[[(tri phenylmethyl)thio]methyl]-2-butenyl]amino]-7-oxoheptyl] ester, (2S)-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1,2-Pyrrolidinedicarboxylic acid, 1-(1,1-dimethylethyl) 2-[(1S,3R,5S,6S)-1-(1,1-dimethylethyl)-5-[[(1,1-dimethylethyl)dimethylsil yl]oxy]-3,6-dimethyl-7-[[(1S,2E)-3-methyl-4-oxo-4-(2-propenyloxy)-1-[[(tri phenylmethyl)thio]methyl]-2-butenyl]amino]-7-oxoheptyl] ester, (2S)-

There total 21 articles about 1,2-Pyrrolidinedicarboxylic acid, 1-(1,1-dimethylethyl) 2-[(1S,3R,5S,6S)-1-(1,1-dimethylethyl)-5-[[(1,1-dimethylethyl)dimethylsil yl]oxy]-3,6-dimethyl-7-[[(1S,2E)-3-methyl-4-oxo-4-(2-propenyloxy)-1-[[(tri phenylmethyl)thio]methyl]-2-butenyl]amino]-7-oxoheptyl] ester, (2S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 878626-87-0
(S)-5,5-dimethyl-4-(4-methoxybenzyloxy)-2-hexanone

: 878626-80-3
(S)-Pyrrolidine-1,2-dicarboxylic acid 2-[(1S,3R,5S,6S)-6-((E)-(S)-3-allyloxycarbonyl-1-tritylsulfanylmethyl-but-2-enylcarbamoyl)-1-tert-butyl-5-(tert-butyl-dimethyl-silanyloxy)-3-methyl-heptyl] ester 1-tert-butyl ester

Guidance literature:: Multi-step reaction with 13 steps

1.1: tetrahydrofuran / 0.5 h / 0 °C

2.1: pyridine; DMAP / 24 h / 50 °C

3.1: PdCl₂(CH₃CN)2 / tetrahydrofuran / 2 h / 20 °C

4.1: 3.29 g / K₂CO₃ / methanol / 1.5 h / 0 °C

5.1: 100 percent / H₂ / Ru(OAc)2[(S)-binap] / methanol / 24 h / 50 °C

6.1: 96 percent / oxalyl chloride; DMSO; Et₃N / CH₂Cl₂ / -78 - 0 °C

7.1: (c-hex)2BCl; Me₂NEt / diethyl ether / 15 h / -78 - -20 °C

8.1: 894 mg / 2,6-lutidine / CH₂Cl₂ / 0.5 h / 0 °C

9.1: DDQ / CH₂Cl₂; H₂O / 0.5 h / 0 °C / pH 7

10.1: iPr₂NEt; 2,4,6-trichlorobenzoyl chloride / tetrahydrofuran / 10 h / 20 °C

10.2: 78 percent / DMAP / toluene / 3 h / 20 °C

11.1: K₂CO₃ / methanol / 1.5 h / 20 °C

12.1: 445 mg / NaIO₄ / 2-methyl-propan-2-ol; H₂O / 2 h / 20 °C

13.1: 372 mg / iPr₂NEt; HATU / CH₂Cl₂ / 10 h / 20 °C

With pyridine; 2,6-dimethylpyridine; dmap; sodium periodate; oxalyl dichloride; N,N-dimethyl-ethanamine; 2,4,6-trichlorobenzoyl chloride; dicyclohexylboron chloride; hydrogen; potassium carbonate; dimethyl sulfoxide; triethylamine; N-ethyl-N,N-diisopropylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; dichloro bis(acetonitrile) palladium(II); Ru(OCOCH₃)2{(S)-2,2'-bis(diphenylphosphino)-1,1'-dinaphthyl)}; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; tert-butyl alcohol; 6.1: Swern oxidation / 7.1: aldol reaction;
DOI:10.1021/ol052907d

Reference yield:

: (S)-5-(4-Methoxy-benzyloxy)-3,6,6-trimethyl-hept-1-en-3-ol

: 878626-80-3
(S)-Pyrrolidine-1,2-dicarboxylic acid 2-[(1S,3R,5S,6S)-6-((E)-(S)-3-allyloxycarbonyl-1-tritylsulfanylmethyl-but-2-enylcarbamoyl)-1-tert-butyl-5-(tert-butyl-dimethyl-silanyloxy)-3-methyl-heptyl] ester 1-tert-butyl ester

Guidance literature:: Multi-step reaction with 12 steps

1.1: pyridine; DMAP / 24 h / 50 °C

2.1: PdCl₂(CH₃CN)2 / tetrahydrofuran / 2 h / 20 °C

3.1: 3.29 g / K₂CO₃ / methanol / 1.5 h / 0 °C

4.1: 100 percent / H₂ / Ru(OAc)2[(S)-binap] / methanol / 24 h / 50 °C

5.1: 96 percent / oxalyl chloride; DMSO; Et₃N / CH₂Cl₂ / -78 - 0 °C

6.1: (c-hex)2BCl; Me₂NEt / diethyl ether / 15 h / -78 - -20 °C

7.1: 894 mg / 2,6-lutidine / CH₂Cl₂ / 0.5 h / 0 °C

8.1: DDQ / CH₂Cl₂; H₂O / 0.5 h / 0 °C / pH 7

9.1: iPr₂NEt; 2,4,6-trichlorobenzoyl chloride / tetrahydrofuran / 10 h / 20 °C

9.2: 78 percent / DMAP / toluene / 3 h / 20 °C

10.1: K₂CO₃ / methanol / 1.5 h / 20 °C

11.1: 445 mg / NaIO₄ / 2-methyl-propan-2-ol; H₂O / 2 h / 20 °C

12.1: 372 mg / iPr₂NEt; HATU / CH₂Cl₂ / 10 h / 20 °C

With pyridine; 2,6-dimethylpyridine; dmap; sodium periodate; oxalyl dichloride; N,N-dimethyl-ethanamine; 2,4,6-trichlorobenzoyl chloride; dicyclohexylboron chloride; hydrogen; potassium carbonate; dimethyl sulfoxide; triethylamine; N-ethyl-N,N-diisopropylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; dichloro bis(acetonitrile) palladium(II); Ru(OCOCH₃)2{(S)-2,2'-bis(diphenylphosphino)-1,1'-dinaphthyl)}; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; tert-butyl alcohol; 5.1: Swern oxidation / 6.1: aldol reaction;
DOI:10.1021/ol052907d

Reference yield:

: 878626-77-8
(E)-(S)-5-(4-methoxybenzyloxy)-3,6,6-trimethyl-2-hepten-1-ol

: 878626-80-3
(S)-Pyrrolidine-1,2-dicarboxylic acid 2-[(1S,3R,5S,6S)-6-((E)-(S)-3-allyloxycarbonyl-1-tritylsulfanylmethyl-but-2-enylcarbamoyl)-1-tert-butyl-5-(tert-butyl-dimethyl-silanyloxy)-3-methyl-heptyl] ester 1-tert-butyl ester

Guidance literature:: Multi-step reaction with 9 steps

1.1: 100 percent / H₂ / Ru(OAc)2[(S)-binap] / methanol / 24 h / 50 °C

2.1: 96 percent / oxalyl chloride; DMSO; Et₃N / CH₂Cl₂ / -78 - 0 °C

3.1: (c-hex)2BCl; Me₂NEt / diethyl ether / 15 h / -78 - -20 °C

4.1: 894 mg / 2,6-lutidine / CH₂Cl₂ / 0.5 h / 0 °C

5.1: DDQ / CH₂Cl₂; H₂O / 0.5 h / 0 °C / pH 7

6.1: iPr₂NEt; 2,4,6-trichlorobenzoyl chloride / tetrahydrofuran / 10 h / 20 °C

6.2: 78 percent / DMAP / toluene / 3 h / 20 °C

7.1: K₂CO₃ / methanol / 1.5 h / 20 °C

8.1: 445 mg / NaIO₄ / 2-methyl-propan-2-ol; H₂O / 2 h / 20 °C

9.1: 372 mg / iPr₂NEt; HATU / CH₂Cl₂ / 10 h / 20 °C

With 2,6-dimethylpyridine; sodium periodate; oxalyl dichloride; N,N-dimethyl-ethanamine; 2,4,6-trichlorobenzoyl chloride; dicyclohexylboron chloride; hydrogen; potassium carbonate; dimethyl sulfoxide; triethylamine; N-ethyl-N,N-diisopropylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; Ru(OCOCH₃)2{(S)-2,2'-bis(diphenylphosphino)-1,1'-dinaphthyl)}; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; tert-butyl alcohol; 2.1: Swern oxidation / 3.1: aldol reaction;
DOI:10.1021/ol052907d