Hexanoic acid, 4-[[(2S)-2-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-1-oxo-3-[(triphenyl methyl)thio]propyl]amino]-3-hydroxy-5-methyl-, 2-propenyl ester, (3S,4R)-

Base Information

Chemical Name:Hexanoic acid, 4-[[(2S)-2-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-1-oxo-3-[(triphenyl methyl)thio]propyl]amino]-3-hydroxy-5-methyl-, 2-propenyl ester, (3S,4R)-
CAS No.:878630-49-0
Molecular Formula:C47H48N2O6S
Molecular Weight:768.974
Hs Code.:

Hexanoic acid,
4-[[(2S)-2-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-1-oxo-3-[(triphenyl
methyl)thio]propyl]amino]-3-hydroxy-5-methyl-, 2-propenyl ester,
(3S,4R)-

Synonyms:

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Chemical Property of Hexanoic acid, 4-[[(2S)-2-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-1-oxo-3-[(triphenyl methyl)thio]propyl]amino]-3-hydroxy-5-methyl-, 2-propenyl ester, (3S,4R)-

Chemical Property:

Purity/Quality:

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Technology Process of Hexanoic acid, 4-[[(2S)-2-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-1-oxo-3-[(triphenyl methyl)thio]propyl]amino]-3-hydroxy-5-methyl-, 2-propenyl ester, (3S,4R)-

There total 5 articles about Hexanoic acid, 4-[[(2S)-2-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-1-oxo-3-[(triphenyl methyl)thio]propyl]amino]-3-hydroxy-5-methyl-, 2-propenyl ester, (3S,4R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 878630-46-7
(3S,4R)-4-tert-Butoxycarbonylamino-3-hydroxy-5-methyl-hexanoic acid allyl ester

: 167015-11-4
Fmoc-D-Cys(Trt)-OH

: 878630-49-0
(3S,4R)-4-[(S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-tritylsulfanyl-propionylamino]-3-hydroxy-5-methyl-hexanoic acid allyl ester

Guidance literature:: (3S,4R)-4-tert-Butoxycarbonylamino-3-hydroxy-5-methyl-hexanoic acid allyl ester; With chloro-trimethyl-silane; trifluorormethanesulfonic acid; PS-DES; In dichloromethane; at 20 ℃; for 12h;

With 2,6-dimethylpyridine; trimethylsilyl trifluoromethanesulfonate; In dichloromethane; at 20 ℃; for 3h;

Fmoc-D-Cys(Trt)-OH; Further stages;
DOI:10.1016/j.tet.2015.07.064

Reference yield:

: 878630-46-7
(3S,4R)-4-tert-Butoxycarbonylamino-3-hydroxy-5-methyl-hexanoic acid allyl ester

: 878630-49-0
(3S,4R)-4-[(S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-tritylsulfanyl-propionylamino]-3-hydroxy-5-methyl-hexanoic acid allyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: HCl / ethyl acetate

2: EDCI; HOBt; N,N-diisopropylethylamine

With hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In ethyl acetate;
DOI:10.1016/j.tetlet.2005.12.031

Reference yield:

: 22838-58-0
Boc-D-Val-OH

: 878630-49-0
(3S,4R)-4-[(S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-tritylsulfanyl-propionylamino]-3-hydroxy-5-methyl-hexanoic acid allyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: carbonyldiimidazole / tetrahydrofuran

1.2: NaBH₄ / methanol; tetrahydrofuran

1.3: 34 percent / LiOH / tetrahydrofuran; H₂O

2.1: K₂CO₃

3.1: HCl / ethyl acetate

4.1: EDCI; HOBt; N,N-diisopropylethylamine

With hydrogenchloride; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; 1,1'-carbonyldiimidazole; In tetrahydrofuran; ethyl acetate;
DOI:10.1016/j.tetlet.2005.12.031