Butanedioic acid, [3-[6-(aminoiminomethyl)-1H-benzimidazol-2-yl]-5-[5-(hydroxymethyl)-2- thienyl]-4-[(2-methoxyethoxy)methoxy]phenyl]-, dimethyl ester

Base Information

• Chemical Name: Butanedioic acid, [3-[6-(aminoiminomethyl)-1H-benzimidazol-2-yl]-5-[5-(hydroxymethyl)-2- thienyl]-4-[(2-methoxyethoxy)methoxy]phenyl]-, dimethyl ester
• CAS No.: 878674-64-7
• Molecular Formula: C29H32N4O8S
• Molecular Weight: 596.661

Synonyms:

Chemical Property of Butanedioic acid, [3-[6-(aminoiminomethyl)-1H-benzimidazol-2-yl]-5-[5-(hydroxymethyl)-2- thienyl]-4-[(2-methoxyethoxy)methoxy]phenyl]-, dimethyl ester

Chemical Property:

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Technology Process of Butanedioic acid, [3-[6-(aminoiminomethyl)-1H-benzimidazol-2-yl]-5-[5-(hydroxymethyl)-2- thienyl]-4-[(2-methoxyethoxy)methoxy]phenyl]-, dimethyl ester

There total 1 articles about Butanedioic acid, [3-[6-(aminoiminomethyl)-1H-benzimidazol-2-yl]-5-[5-(hydroxymethyl)-2- thienyl]-4-[(2-methoxyethoxy)methoxy]phenyl]-, dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-[3-formyl-5-(5-hydroxymethyl-thiophen-2-yl)-4-(2-methoxy-ethoxymethoxy)-phenyl]-succinic acid dimethyl ester + 3,4-diaminobenzamidine monohydrochloride → 2-[3-(5-carbamimidoyl-1H-benzoimidazol-2-yl)-5-(5-hydroxymethyl-thiophen-2-yl)-4-(2-methoxy-ethoxymethoxy)-phenyl]-succinic acid dimethyl ester (878674-64-7)

Guidance literature:

With p-benzoquinone; In methanol; for 6h; Heating;

DOI:10.1016/j.bmcl.2005.12.040

Reference yield:

2-[3-(5-carbamimidoyl-1H-benzoimidazol-2-yl)-5-(5-hydroxymethyl-thiophen-2-yl)-4-(2-methoxy-ethoxymethoxy)-phenyl]-succinic acid dimethyl ester (878674-64-7) → 2-[3-(5-carbamimidoyl-1H-benzoimidazol-2-yl)-4-hydroxy-5-(5-hydroxymethyl-thiophen-2-yl)-phenyl]-succinic acid dimethyl ester

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; methanol; for 1h;

DOI:10.1016/j.bmcl.2005.12.040

Reference yield:

2-[3-(5-carbamimidoyl-1H-benzoimidazol-2-yl)-5-(5-hydroxymethyl-thiophen-2-yl)-4-(2-methoxy-ethoxymethoxy)-phenyl]-succinic acid dimethyl ester (878674-64-7) → 2-[3-(5-carbamimidoyl-1H-benzoimidazol-2-yl)-4-hydroxy-5-(5-hydroxymethyl-thiophen-2-yl)-phenyl]-succinic acid

Guidance literature:

Multi-step reaction with 2 steps

1: HCl / dioxane; methanol / 1 h

2: aq. HCl / 1 h / Heating

With hydrogenchloride; In 1,4-dioxane; methanol;

DOI:10.1016/j.bmcl.2005.12.040

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