2-Pyrrolidinemethanol, 1-[[(1R,2R,3R,4S)-2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-4-(hexadecyl oxy)-3-(phenylmethoxy)cyclopentyl]methyl]-, (2S)-

Base Information

Chemical Name:2-Pyrrolidinemethanol, 1-[[(1R,2R,3R,4S)-2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-4-(hexadecyl oxy)-3-(phenylmethoxy)cyclopentyl]methyl]-, (2S)-
CAS No.:878675-49-1
Molecular Formula:C₄₀H₇₃NO₄Si
Molecular Weight:660.109
Hs Code.:

2-Pyrrolidinemethanol,
1-[[(1R,2R,3R,4S)-2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-4-(hexadecyl
oxy)-3-(phenylmethoxy)cyclopentyl]methyl]-, (2S)-

Synonyms:

Suppliers and Price of 2-Pyrrolidinemethanol, 1-[[(1R,2R,3R,4S)-2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-4-(hexadecyl oxy)-3-(phenylmethoxy)cyclopentyl]methyl]-, (2S)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-Pyrrolidinemethanol, 1-[[(1R,2R,3R,4S)-2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-4-(hexadecyl oxy)-3-(phenylmethoxy)cyclopentyl]methyl]-, (2S)-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-Pyrrolidinemethanol, 1-[[(1R,2R,3R,4S)-2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-4-(hexadecyl oxy)-3-(phenylmethoxy)cyclopentyl]methyl]-, (2S)-

There total 12 articles about 2-Pyrrolidinemethanol, 1-[[(1R,2R,3R,4S)-2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-4-(hexadecyl oxy)-3-(phenylmethoxy)cyclopentyl]methyl]-, (2S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (2R,4aR,6S,7R,8S,8aS)-7-Hexadecyloxy-6-methoxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-8-ol

: 878675-49-1
{(S)-1-[(1R,2R,3R,4S)-3-Benzyloxy-2-(tert-butyl-dimethyl-silanyloxy)-4-hexadecyloxy-cyclopentylmethyl]-pyrrolidin-2-yl}-methanol

Guidance literature:: Multi-step reaction with 10 steps

1: 72 percent / NaH / dimethylformamide; tetrahydrofuran / 3 h / 20 °C

2: 100 percent / CSA / methanol / 1 h / Heating

3: 74 percent / I₂; PPh₃; imidazole / toluene / 0.5 h / Heating

4: 100 percent / pyridine / CH₂Cl₂ / 2.5 h / 20 °C

5: Zn powder; pyridine / ethanol / 4 h / Heating

6: NaBH₄ / ethanol / 0.5 h / 20 °C

7: 89 percent / PPh₃; imidazole; I₂ / toluene / 0.5 h / Heating

8: 78 percent / NaBH₄; NaOH; air / Co(salen) / aq. ethanol / 2.5 h / 40 °C

9: PCC; NaOAc / CH₂Cl₂ / 2 h / 20 °C

10: 62 percent / NaBH₃CN; AcOH / methanol / 2 h / Heating

With pyridine; 1H-imidazole; sodium hydroxide; sodium tetrahydroborate; air; camphor-10-sulfonic acid; iodine; sodium acetate; sodium hydride; sodium cyanoborohydride; acetic acid; triphenylphosphine; pyridinium chlorochromate; zinc; salcomine; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene; 3: Garreg's iodination / 7: Garreg's iodination;
DOI:10.1016/j.tetlet.2005.12.029

Reference yield:

: 878675-43-5
(2R,3R,4S,5R,6S)-4-Benzyloxy-5-hexadecyloxy-2-hydroxymethyl-6-methoxy-tetrahydro-pyran-3-ol

: 878675-49-1
{(S)-1-[(1R,2R,3R,4S)-3-Benzyloxy-2-(tert-butyl-dimethyl-silanyloxy)-4-hexadecyloxy-cyclopentylmethyl]-pyrrolidin-2-yl}-methanol

Guidance literature:: Multi-step reaction with 8 steps

1: 74 percent / I₂; PPh₃; imidazole / toluene / 0.5 h / Heating

2: 100 percent / pyridine / CH₂Cl₂ / 2.5 h / 20 °C

3: Zn powder; pyridine / ethanol / 4 h / Heating

4: NaBH₄ / ethanol / 0.5 h / 20 °C

5: 89 percent / PPh₃; imidazole; I₂ / toluene / 0.5 h / Heating

6: 78 percent / NaBH₄; NaOH; air / Co(salen) / aq. ethanol / 2.5 h / 40 °C

7: PCC; NaOAc / CH₂Cl₂ / 2 h / 20 °C

8: 62 percent / NaBH₃CN; AcOH / methanol / 2 h / Heating

With pyridine; 1H-imidazole; sodium hydroxide; sodium tetrahydroborate; air; iodine; sodium acetate; sodium cyanoborohydride; acetic acid; triphenylphosphine; pyridinium chlorochromate; zinc; salcomine; In methanol; ethanol; dichloromethane; toluene; 1: Garreg's iodination / 5: Garreg's iodination;
DOI:10.1016/j.tetlet.2005.12.029

Reference yield:

: (2R,3R,4R)-3-Benzyloxy-4-(tert-butyl-dimethyl-silanyloxy)-2-hexadecyloxy-hex-5-enal

: 878675-49-1
{(S)-1-[(1R,2R,3R,4S)-3-Benzyloxy-2-(tert-butyl-dimethyl-silanyloxy)-4-hexadecyloxy-cyclopentylmethyl]-pyrrolidin-2-yl}-methanol

Guidance literature:: Multi-step reaction with 5 steps

1: NaBH₄ / ethanol / 0.5 h / 20 °C

2: 89 percent / PPh₃; imidazole; I₂ / toluene / 0.5 h / Heating

3: 78 percent / NaBH₄; NaOH; air / Co(salen) / aq. ethanol / 2.5 h / 40 °C

4: PCC; NaOAc / CH₂Cl₂ / 2 h / 20 °C

5: 62 percent / NaBH₃CN; AcOH / methanol / 2 h / Heating

With 1H-imidazole; sodium hydroxide; sodium tetrahydroborate; air; iodine; sodium acetate; sodium cyanoborohydride; acetic acid; triphenylphosphine; pyridinium chlorochromate; salcomine; In methanol; ethanol; dichloromethane; toluene; 2: Garreg's iodination;
DOI:10.1016/j.tetlet.2005.12.029