3-cyclopropylpicolinic acid

Base Information

• Chemical Name: 3-cyclopropylpicolinic acid
• CAS No.: 878805-23-3
• Molecular Formula: C₉H₉NO₂
• Molecular Weight: 163.176
• Hs Code.: 2933399090
• Mol file: 878805-23-3.mol

Synonyms:3-cyclopropylpicolinic acid;

Chemical Property of 3-cyclopropylpicolinic acid

Chemical Property:

• Boiling Point: 310.4±30.0 °C(Predicted)
• PKA: 1.11±0.50(Predicted)
• PSA: 50.19000
• Density: 1.324±0.06 g/cm3(Predicted)
• LogP: 1.65720
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

3-Cyclopropylpicolinicacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-cyclopropylpicolinic acid

There total 4 articles about 3-cyclopropylpicolinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 3-cyclopropylpyridine-2-carboxylate (878805-24-4) → 3-cyclopropylpyridine-2-carboxylic acid (878805-23-3)

Guidance literature:

With methanol; sodium hydroxide; water; at 50 ℃; for 0.5h;

Reference yield:

3-bromopicolinic acid (30683-23-9) → 3-cyclopropylpyridine-2-carboxylic acid (878805-23-3)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sulfuric acid / 2 h / Reflux

2.1: triethylamine / isopropyl alcohol / 0.25 h / Inert atmosphere

2.2: 4 h / 100 °C

3.1: diethylzinc / dichloromethane; hexane / 0.5 h / -10 °C / Inert atmosphere

3.2: 15.25 h / -10 - 20 °C

4.1: water; lithium hydroxide / tetrahydrofuran / 2 h / Reflux

With sulfuric acid; water; diethylzinc; triethylamine; lithium hydroxide; In tetrahydrofuran; hexane; dichloromethane; isopropyl alcohol;

Reference yield:

methyl 3-bromopicolinate (53636-56-9) → 3-cyclopropylpyridine-2-carboxylic acid (878805-23-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: triethylamine / isopropyl alcohol / 0.25 h / Inert atmosphere

1.2: 4 h / 100 °C

2.1: diethylzinc / dichloromethane; hexane / 0.5 h / -10 °C / Inert atmosphere

2.2: 15.25 h / -10 - 20 °C

3.1: water; lithium hydroxide / tetrahydrofuran / 2 h / Reflux

With water; diethylzinc; triethylamine; lithium hydroxide; In tetrahydrofuran; hexane; dichloromethane; isopropyl alcohol;

upstream raw materials:

methyl 3-cyclopropylpyridine-2-carboxylate

3-bromopicolinic acid

methyl 3-bromopicolinate

methyl 3-vinylpicolinate

Downstream raw materials:

2-amino-3-cyclopropylpyridine