Climazolam

Base Information

Chemical Name:Climazolam
CAS No.:59467-77-5
Molecular Formula:C18H13 Cl2 N3
Molecular Weight:342.227
Hs Code.:
UNII:O9KZB9HG1Y
DSSTox Substance ID:DTXSID30208173
Nikkaji Number:J23.286F
Wikipedia:Climazolam
Wikidata:Q5133651
NCI Thesaurus Code:C77636
ChEMBL ID:CHEMBL2104070
Mol file:59467-77-5.mol

Synonyms:8-chloro-6-(2-chlorophenyl)-1-methyl-4H-imidazo(1,5a)(1,4)benzodiazepine;climazolam;Ro 21-3982

Suppliers and Price of Climazolam

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
CLIMAZOLAM 95.00%
5MG
$ 502.96

Total 31 raw suppliers

Chemical Property of Climazolam

Chemical Property:

Vapor Pressure:5.07E-11mmHg at 25°C
Boiling Point:522.7°C at 760 mmHg
PKA:6.05±0.40(Predicted)
Flash Point:269.9°C
PSA：30.18000
Density:1.38g/cm³
LogP:4.27410
XLogP3:3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:341.0486528
Heavy Atom Count:23
Complexity:469

Purity/Quality:

99% ^*data from raw suppliers

CLIMAZOLAM 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=NC=C2N1C3=C(C=C(C=C3)Cl)C(=NC2)C4=CC=CC=C4Cl
Description Climazolam is a potent benzodiazepine which, following IV administration, has a very rapid onset of effect. It has a marketing authorization in Switzerland for use in dogs, but has been used in a wide variety of animals including cattle, sheep, horses and dogs (Rehm & Schatzmann, 1984). It is used as part of anaesthetic combinations. It is particularly effective for use with ketamine and, in horses, this combination has been used by constant rate infusion (CRI) to produce total intravenous anaesthesia (TIVA), the climazolam being reversed with sarmazenil (see below) at the end of surgery to produce a rapid recovery (BettschartWolfensberger et al., 1996). Climazolam (1.0–1.5 mg/kg) has also been used in combination with fentanyl (0.005–0.015 mg/kg) for anaesthesia in the dog (Erhardt et al., 1986).
Uses Climazolam (Ro21-3982) was introduced under licence as a veterinary medicine by the Swiss Pharmaceutical company Gr?ub under the tradename Climasol. Climazolam is a benzodiazepine, specifically an imidazobenzodiazepine derivative developed by Hoffman-LaRoche. It is similar in structure to midazolam and diclazepam and is used in veterinary medicine for anesthetizing animals.
Indications Climazolam: an injectable benzodiazepine approved in Europe for anesthesia in dogs and cats, for example, as premedication with an opioid or for induction with ketamine.Climazolam is a possible alternative to midazolam, but its use will require a relaxing of the import regulations by Health Canada and of the minimum practice standards of the OMVQ (which encourages the use of approved drugs), since it is not approved in Canada.If climazolam were approved in Canada (it is approved in Europe for dogs and cats), it could replace diazepam or midazolam in combination with ketamine or other induction agents.

Technology Process of Climazolam

There total 3 articles about Climazolam which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 59467-76-4
8-chloro-6-(2-chlorophenyl)-3a,4-dihydro-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine

: 59467-77-5
8-chloro-6-(2-chloro-phenyl)-1-methyl-4H-benzo[f]imidazo[1,5-a][1,4]diazepine

Guidance literature:: With enzyme-containing bacterial cell from Arthrobacter sp.; at 25 ℃; for 35h; pH=6.5; Concentration; Enzymatic reaction;

Reference yield:

: 2-aminomethyl-7-chloro-5-(2-chlorophenyl)-2,3-dihydro-1H-1,4-benzodiazepine

: 59467-77-5
8-chloro-6-(2-chloro-phenyl)-1-methyl-4H-benzo[f]imidazo[1,5-a][1,4]diazepine

Guidance literature:: Multi-step reaction with 2 steps

1: 3 h / Sonication

2: enzyme-containing bacterial cell from Arthrobacter sp. / 35 h / 25 °C / pH 6.5 / Enzymatic reaction

With enzyme-containing bacterial cell from Arthrobacter sp.;