Isoquinoline, 1,2,3,4-tetrahydro-8-(4-hydroxyphenyl)-6,7-dimethoxy-1-methylene-2-(tri fluoroacetyl)-

Base Information

Chemical Name:Isoquinoline, 1,2,3,4-tetrahydro-8-(4-hydroxyphenyl)-6,7-dimethoxy-1-methylene-2-(tri fluoroacetyl)-
CAS No.:879286-36-9
Molecular Formula:C20H18F3NO4
Molecular Weight:393.362
Hs Code.:

Synonyms:

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Chemical Property of Isoquinoline, 1,2,3,4-tetrahydro-8-(4-hydroxyphenyl)-6,7-dimethoxy-1-methylene-2-(tri fluoroacetyl)-

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of Isoquinoline, 1,2,3,4-tetrahydro-8-(4-hydroxyphenyl)-6,7-dimethoxy-1-methylene-2-(tri fluoroacetyl)-

There total 9 articles about Isoquinoline, 1,2,3,4-tetrahydro-8-(4-hydroxyphenyl)-6,7-dimethoxy-1-methylene-2-(tri fluoroacetyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 879286-33-6
3-(4'-hydroxyphenyl)-4,5-dimethoxybenzaldehyde

: 879286-36-9
2,2,2-trifluoro-1-[8-(4-hydroxy-phenyl)-6,7-dimethoxy-1-methylene-3,4-dihydro-1H-isoquinolin-2-yl]-ethanone

Guidance literature:: Multi-step reaction with 7 steps

1: 92 percent / K₂CO₃; KI / acetone / 6 h / 20 °C

2: NH₄OAc / 3 h / 80 °C

3: LiAlH₄ / tetrahydrofuran / 15 h / Heating

4: 872 mg / Et₃N / CH₂Cl₂ / 5 h / 0 °C

5: H₂ / Pd(OH)2 / methanol / 10 h / 20 °C

6: POCl₃ / acetonitrile / 3.5 h / 50 °C

7: 305 mg / Et₃N / CH₂Cl₂ / 0.33 h / 0 °C

With lithium aluminium tetrahydride; ammonium acetate; hydrogen; potassium carbonate; triethylamine; potassium iodide; trichlorophosphate; palladium dihydroxide; In tetrahydrofuran; methanol; dichloromethane; acetone; acetonitrile; 6: Bischler-Napieralski cyclization;
DOI:10.1021/ol052841m

Reference yield:

: 879286-34-7
3-(4'-benzyloxyphenyl)-4,5-dimethoxybenzaldehyde

: 879286-36-9
2,2,2-trifluoro-1-[8-(4-hydroxy-phenyl)-6,7-dimethoxy-1-methylene-3,4-dihydro-1H-isoquinolin-2-yl]-ethanone

Guidance literature:: Multi-step reaction with 6 steps

1: NH₄OAc / 3 h / 80 °C

2: LiAlH₄ / tetrahydrofuran / 15 h / Heating

3: 872 mg / Et₃N / CH₂Cl₂ / 5 h / 0 °C

4: H₂ / Pd(OH)2 / methanol / 10 h / 20 °C

5: POCl₃ / acetonitrile / 3.5 h / 50 °C

6: 305 mg / Et₃N / CH₂Cl₂ / 0.33 h / 0 °C

With lithium aluminium tetrahydride; ammonium acetate; hydrogen; triethylamine; trichlorophosphate; palladium dihydroxide; In tetrahydrofuran; methanol; dichloromethane; acetonitrile; 5: Bischler-Napieralski cyclization;
DOI:10.1021/ol052841m

Reference yield:

: 4'-Benzyloxy-2,3-dimethoxy-5-((E)-2-nitro-vinyl)-biphenyl

: 879286-36-9
2,2,2-trifluoro-1-[8-(4-hydroxy-phenyl)-6,7-dimethoxy-1-methylene-3,4-dihydro-1H-isoquinolin-2-yl]-ethanone

Guidance literature:: Multi-step reaction with 5 steps

1: LiAlH₄ / tetrahydrofuran / 15 h / Heating

2: 872 mg / Et₃N / CH₂Cl₂ / 5 h / 0 °C

3: H₂ / Pd(OH)2 / methanol / 10 h / 20 °C

4: POCl₃ / acetonitrile / 3.5 h / 50 °C

5: 305 mg / Et₃N / CH₂Cl₂ / 0.33 h / 0 °C

With lithium aluminium tetrahydride; hydrogen; triethylamine; trichlorophosphate; palladium dihydroxide; In tetrahydrofuran; methanol; dichloromethane; acetonitrile; 4: Bischler-Napieralski cyclization;
DOI:10.1021/ol052841m