Bis(5-fluoro-2,4-dimethoxyphenyl)methanone

Base Information

Chemical Name:Bis(5-fluoro-2,4-dimethoxyphenyl)methanone
CAS No.:879288-16-1
Molecular Formula:C17H16F2O5
Molecular Weight:338.308
Hs Code.:
DSSTox Substance ID:DTXSID701265369
Nikkaji Number:J2.286.755E

Synonyms:bis(5-fluoro-2,4-dimethoxyphenyl)methanone;DTXSID701265369;879288-16-1

Suppliers and Price of Bis(5-fluoro-2,4-dimethoxyphenyl)methanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Bis(5-fluoro-2,4-dimethoxyphenyl)methanone

Chemical Property:

XLogP3:3.4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:6
Exact Mass:338.09657993
Heavy Atom Count:24
Complexity:386

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=CC(=C(C=C1C(=O)C2=CC(=C(C=C2OC)OC)F)F)OC

Technology Process of Bis(5-fluoro-2,4-dimethoxyphenyl)methanone

There total 8 articles about Bis(5-fluoro-2,4-dimethoxyphenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 879288-15-0
1-fluoro-5-iodo-2,4-dimethoxybenzene

: 879288-16-1
bis(5-fluoro-2,4-dimethoxyphenyl)methanone

Guidance literature:: In acetonitrile; for 0.00555556h; microwave irradiation;
DOI:10.1021/ol052655g

Reference yield:

: 17715-70-7
1,3-dimethoxy-4-fluorobenzene

: 2,4-dimethoxy-5-fluorobenzoyl chloride

: 879288-16-1
bis(5-fluoro-2,4-dimethoxyphenyl)methanone

Guidance literature:: With aluminium trichloride; In dichloromethane; at 0 - 20 ℃; for 68h;
DOI:10.1021/ja017530v

Reference yield:

: 2105-61-5
1,2,4-trifluoro-5-nitrobenzene

: 879288-16-1
bis(5-fluoro-2,4-dimethoxyphenyl)methanone

Guidance literature:: Multi-step reaction with 4 steps

1: 92 percent / methanol

2: 91 percent / H₂ / Pd/C / ethanol

3: 68 percent / HCl; NaNO₂; NaI / H₂O / 16 h / 0 - 22 °C

4: 96 percent / acetonitrile / 0.01 h / microwave irradiation

With hydrogenchloride; hydrogen; sodium iodide; sodium nitrite; palladium on activated charcoal; In methanol; ethanol; water; acetonitrile; 3: Sandmeyer reaction;
DOI:10.1021/ol052655g