Phenethylhydrazine dihydrochloride

Base Information

• Chemical Name: Phenethylhydrazine dihydrochloride
• CAS No.: 16904-30-6
• Molecular Formula: C₈H₁₂N₂*ClH
• Molecular Weight: 172.658
• Hs Code.: 2928000090
• European Community (EC) Number: 835-550-8
• DSSTox Substance ID: DTXSID70168641
• Mol file: 16904-30-6.mol

Synonyms:phenethylhydrazine dihydrochloride;16904-30-6;Phelasin;Phelazine;1-(2-phenylethyl)hydrazine dihydrochloride;USAF LA-10;Phenelzine dihydrochloride;HYDRAZINE, PHENETHYL-, DIHYDROCHLORIDE;2-Phenyl-ethyl hydrazine dihydrochloride;2-phenylethylhydrazine;dihydrochloride;Hydrazine, (2-phenylethyl)-, dihydrochloride;(2-phenylethyl)hydrazine dihydrochloride;phenethylhydrazinedihydrochloride;SCHEMBL2786042;DTXSID70168641;AC4670;MFCD01722349;AKOS030627361;BS-52201;LS-76935;SY048081;EN300-41855;Z927192062

Chemical Property of Phenethylhydrazine dihydrochloride

Chemical Property:

• Vapor Pressure: 0.00358mmHg at 25°C
• Boiling Point: 281.4°C at 760 mmHg
• Flash Point: 143.7°C
• PSA: 38.05000
• LogP: 3.38760
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 208.0534038
• Heavy Atom Count: 12
• Complexity: 77.3

Purity/Quality:

99% ^*data from raw suppliers

(2-phenylethyl)hydrazinedihydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)CCNN.Cl.Cl

Technology Process of Phenethylhydrazine dihydrochloride

There total 2 articles about Phenethylhydrazine dihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

C16H24N2O2 (1251463-81-6) → phenethylhydrazine dihydrochloride (16904-30-6,77430-25-2)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; water; Reflux;

Reference yield: 52.0%

1-phenyl-2-bromoethane (103-63-9) → [2-(phenyl)ethyl]hydrazine hydrochloride (5470-36-0,16904-30-6,77430-25-2)

Guidance literature:

1-phenyl-2-bromoethane; With hydrazine hydrate; In ethanol; for 2h; Reflux; Inert atmosphere;

With hydrogenchloride; In water; Inert atmosphere;

DOI:10.1002/anie.201207533

Reference yield: 95.0%

[2-(phenyl)ethyl]hydrazine hydrochloride (5470-36-0,16904-30-6,77430-25-2) + 4-methoxy-3,4,5-trimethylcyclohexa-2,5-dienone → C17H17N (1431660-77-3)

Guidance literature:

With pyridine; In chloroform; at 90 ℃; for 6h; Inert atmosphere;

DOI:10.1002/anie.201207533

upstream raw materials:

1-phenyl-2-bromoethane

C₁₆H₂₄N₂O₂

Downstream raw materials:

1-phenethylhydrazinecarbothioamide

1-amino-1-phenethylguanidine

3-methyl-1-(2-phenethyl)pyrazole

C₁₅H₁₁Cl₂NO

Refernces

• 1、 Zhang, Jinzhu,Yin, Zhiwei,Leonard, Patrick,Wu, Jing,Sioson, Kate,Liu, Che,Lapo, Robert,Zheng, Shengping. "A variation of the Fischer indolization involving condensation of quinone monoketals and aliphatic hydrazines". supporting information. p. 1753 - 1757,5. Retrieved 2013/04/10.