1-Piperazinecarboxylic acid, 4-[4-[[2-(acetylamino)-4-benzothiazolyl]oxy]-6-[4-(trifluoromethyl)phenyl]- 2-pyrimidinyl]-, 1,1-dimethylethyl ester

Base Information

• Chemical Name: 1-Piperazinecarboxylic acid, 4-[4-[[2-(acetylamino)-4-benzothiazolyl]oxy]-6-[4-(trifluoromethyl)phenyl]- 2-pyrimidinyl]-, 1,1-dimethylethyl ester
• CAS No.: 879598-51-3
• Molecular Formula: C29H29F3N6O4S
• Molecular Weight: 614.648

Synonyms:

Chemical Property of 1-Piperazinecarboxylic acid, 4-[4-[[2-(acetylamino)-4-benzothiazolyl]oxy]-6-[4-(trifluoromethyl)phenyl]- 2-pyrimidinyl]-, 1,1-dimethylethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-Piperazinecarboxylic acid, 4-[4-[[2-(acetylamino)-4-benzothiazolyl]oxy]-6-[4-(trifluoromethyl)phenyl]- 2-pyrimidinyl]-, 1,1-dimethylethyl ester

There total 1 articles about 1-Piperazinecarboxylic acid, 4-[4-[[2-(acetylamino)-4-benzothiazolyl]oxy]-6-[4-(trifluoromethyl)phenyl]- 2-pyrimidinyl]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-{4-[2-chloro-6-(4-trifluoromethyl-phenyl)-pyrimidin-4-yloxy]-benzothiazol-2-yl}-acetamide (879608-98-7) + 1-t-Butoxycarbonylpiperazine (57260-71-6) → tert-butyl 4-(4-(2-acetamidobenzo[d]thiazol-4-yloxy)-6-(4-(trifluoromethyl)phenyl)pyrimidin-2-yl)piperazine-1-carboxylate (879598-51-3)

Guidance literature:

In ethanol; at 140 ℃; for 0.5h; microwave irradiation;

DOI:10.1016/j.bmcl.2007.09.080

Reference yield: 87.0%

tert-butyl 4-(4-(2-acetamidobenzo[d]thiazol-4-yloxy)-6-(4-(trifluoromethyl)phenyl)pyrimidin-2-yl)piperazine-1-carboxylate (879598-51-3) → N-[4-({2-piperazin-1-yl-6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl}oxy)-1,3-benzothiazol-2-yl]acetamide

Guidance literature:

With trifluoroacetic acid; In dichloromethane;

DOI:10.1016/j.bmcl.2007.09.080

Reference yield:

tert-butyl 4-(4-(2-acetamidobenzo[d]thiazol-4-yloxy)-6-(4-(trifluoromethyl)phenyl)pyrimidin-2-yl)piperazine-1-carboxylate (879598-51-3) + trifluoroacetic acid (76-05-1) → N-(4-(2-(piperazin-1-yl)-6-(4-(trifluoromethyl)phenyl)pyrimidin-4-yloxy)benzo[d]thiazol-2-yl)acetamide trifluoroacetic acid salt

Guidance literature:

In 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran; at 20 ℃; for 1.5h;

upstream raw materials:

N-{4-[2-chloro-6-(4-trifluoromethyl-phenyl)-pyrimidin-4-yloxy]-benzothiazol-2-yl}-acetamide

1-t-Butoxycarbonylpiperazine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 879598-51-3 1-Piperazinecarboxylic acid, 4-[4-[[2-(acetylamino)-4-benzothiazolyl]oxy]-6-[4-(trifluoromethyl)phenyl]- 2-pyrimidinyl]-, 1,1-dimethylethyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send