2,5,7,10,13-Pentaazatetradec-5-enedioic acid, 11-oxo-12-[3-oxo-3-(phenylmethoxy)propyl]-6-[(trifluoroacetyl)amino]-, 1-(1,1-dimethylethyl) 14-(9H-fluoren-9-ylmethyl) ester, (12S)-

Base Information

Chemical Name:2,5,7,10,13-Pentaazatetradec-5-enedioic acid, 11-oxo-12-[3-oxo-3-(phenylmethoxy)propyl]-6-[(trifluoroacetyl)amino]-, 1-(1,1-dimethylethyl) 14-(9H-fluoren-9-ylmethyl) ester, (12S)-
CAS No.:879880-77-0
Molecular Formula:C₃₉H₄₅F₃N₆O₈
Molecular Weight:782.817
Hs Code.:

2,5,7,10,13-Pentaazatetradec-5-enedioic acid,
11-oxo-12-[3-oxo-3-(phenylmethoxy)propyl]-6-[(trifluoroacetyl)amino]-,
1-(1,1-dimethylethyl) 14-(9H-fluoren-9-ylmethyl) ester, (12S)-

Synonyms:

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Chemical Property of 2,5,7,10,13-Pentaazatetradec-5-enedioic acid, 11-oxo-12-[3-oxo-3-(phenylmethoxy)propyl]-6-[(trifluoroacetyl)amino]-, 1-(1,1-dimethylethyl) 14-(9H-fluoren-9-ylmethyl) ester, (12S)-

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Technology Process of 2,5,7,10,13-Pentaazatetradec-5-enedioic acid, 11-oxo-12-[3-oxo-3-(phenylmethoxy)propyl]-6-[(trifluoroacetyl)amino]-, 1-(1,1-dimethylethyl) 14-(9H-fluoren-9-ylmethyl) ester, (12S)-

There total 5 articles about 2,5,7,10,13-Pentaazatetradec-5-enedioic acid, 11-oxo-12-[3-oxo-3-(phenylmethoxy)propyl]-6-[(trifluoroacetyl)amino]-, 1-(1,1-dimethylethyl) 14-(9H-fluoren-9-ylmethyl) ester, (12S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: {2-[3-(2-benzyloxycarbonylamino-ethyl)-thioureido]-ethyl}-carbamic acid tert-butyl ester

: 879880-77-0
4-{2-[N'-(2-tert-butoxycarbonylaminoethyl)-N''-(2,2,2-trifluoroacetyl)guanidino]ethylcarbamoyl}-4-(9H-fluoren-9-ylmethoxycarbonylamino)butyric acid benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: acetone

2: NH₄PF₆ / CH₂Cl₂; methanol

3: DBU / toluene; CHCl₃ / Heating

4: H₂ / Pd/C / dimethylformamide / 16 h

5: 73 mg / HOBt; DIPEA; EDC / DMAP / dimethylformamide / 18 h

With ammonium hexafluorophosphate; hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; dmap; palladium on activated charcoal; In methanol; dichloromethane; chloroform; N,N-dimethyl-formamide; acetone; toluene;
DOI:10.1002/chem.200500876

Reference yield:

: 879880-76-9
{2-[N'-(2-benzyloxycarbonylamino-ethyl)-N''-trifluoroacetyl-guanidino]-ethyl}-carbamic acid tert-butyl ester

: 879880-77-0
4-{2-[N'-(2-tert-butoxycarbonylaminoethyl)-N''-(2,2,2-trifluoroacetyl)guanidino]ethylcarbamoyl}-4-(9H-fluoren-9-ylmethoxycarbonylamino)butyric acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: H₂ / Pd/C / dimethylformamide / 16 h

2: 73 mg / HOBt; DIPEA; EDC / DMAP / dimethylformamide / 18 h

With hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; dmap; palladium on activated charcoal; In N,N-dimethyl-formamide;
DOI:10.1002/chem.200500876

Reference yield:

: [1-(2-Benzyloxycarbonylamino-ethylamino)-1-(2-tert-butoxycarbonylamino-ethylamino)-meth-(E)-ylidene]-methyl-sulfonium; iodide

: 879880-77-0
4-{2-[N'-(2-tert-butoxycarbonylaminoethyl)-N''-(2,2,2-trifluoroacetyl)guanidino]ethylcarbamoyl}-4-(9H-fluoren-9-ylmethoxycarbonylamino)butyric acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: NH₄PF₆ / CH₂Cl₂; methanol

2: DBU / toluene; CHCl₃ / Heating

3: H₂ / Pd/C / dimethylformamide / 16 h

4: 73 mg / HOBt; DIPEA; EDC / DMAP / dimethylformamide / 18 h

With ammonium hexafluorophosphate; hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; dmap; palladium on activated charcoal; In methanol; dichloromethane; chloroform; N,N-dimethyl-formamide; toluene;
DOI:10.1002/chem.200500876