4-Piperidin-4-ylmethyl-piperidine-1-carboxylic acid tert-butyl ester

Base Information

• Chemical Name: 4-Piperidin-4-ylmethyl-piperidine-1-carboxylic acid tert-butyl ester
• CAS No.: 879883-54-2
• Molecular Formula: C16H30N2O2
• Molecular Weight: 282.42200
• Mol file: 879883-54-2.mol

Synonyms:

Chemical Property of 4-Piperidin-4-ylmethyl-piperidine-1-carboxylic acid tert-butyl ester

Chemical Property:

• PSA: 41.57000
• LogP: 3.28990
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

98% ^*data from raw suppliers

4-Piperidin-4-ylmethyl-piperidine-1-carboxylicacidtert-butylester 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Piperidin-4-ylmethyl-piperidine-1-carboxylic acid tert-butyl ester

There total 4 articles about 4-Piperidin-4-ylmethyl-piperidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

tert-butyl 4-(pyridin-4-ylmethyl)piperidine-1-carboxylate (333986-17-7) → tert-butyl 4-(piperidin-4-ylmethyl)piperidine-1-carboxylate (879883-54-2)

Guidance literature:

With platinum(IV) oxide; hydrogen; acetic acid; In ethanol; at 20 ℃; for 54h; under 2585.81 Torr;

Reference yield:

tert-butyl 4-methylidenepiperidine-1-carboxylate (159635-49-1) → tert-butyl 4-(piperidin-4-ylmethyl)piperidine-1-carboxylate (879883-54-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 9-borabicyclo[3.3.1]nonane dimer / tetrahydrofuran / 1 h / 80 °C / Inert atmosphere

1.2: 27 h / 60 °C / Inert atmosphere

2.1: acetic acid; hydrogen; platinum(IV) oxide / ethanol / 54 h / 20 °C / 2585.81 Torr

With platinum(IV) oxide; 9-borabicyclo[3.3.1]nonane dimer; hydrogen; acetic acid; In tetrahydrofuran; ethanol;

Reference yield:

4-bromopyridin (1120-87-2) → tert-butyl 4-(piperidin-4-ylmethyl)piperidine-1-carboxylate (879883-54-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 9-borabicyclo[3.3.1]nonane dimer / tetrahydrofuran / 1 h / 80 °C / Inert atmosphere

1.2: 27 h / 60 °C / Inert atmosphere

2.1: acetic acid; hydrogen; platinum(IV) oxide / ethanol / 54 h / 20 °C / 2585.81 Torr

With platinum(IV) oxide; 9-borabicyclo[3.3.1]nonane dimer; hydrogen; acetic acid; In tetrahydrofuran; ethanol;

upstream raw materials:

tert-butyl 4-(pyridin-4-ylmethyl)piperidine-1-carboxylate

4-bromopyridin

tert-butyl 4-methylidenepiperidine-1-carboxylate