4-(6-chloropyridine-3-ylethynyl)benzonitrile

Base Information

Chemical Name:4-(6-chloropyridine-3-ylethynyl)benzonitrile
CAS No.:880266-35-3
Molecular Formula:C14H7ClN2
Molecular Weight:238.67200
Hs Code.:
Mol file:880266-35-3.mol

Synonyms:Benzonitrile, 4-[(6-chloro-3-pyridinyl)ethynyl]-;4-(6-Chloropyridin-3-ylethynyl)benzonitrile;

Suppliers and Price of 4-(6-chloropyridine-3-ylethynyl)benzonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 3 raw suppliers

Chemical Property of 4-(6-chloropyridine-3-ylethynyl)benzonitrile

Chemical Property:

PSA：36.68000
LogP:3.00648

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 4-(6-chloropyridine-3-ylethynyl)benzonitrile

There total 1 articles about 4-(6-chloropyridine-3-ylethynyl)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 53939-30-3
5-bromo-2-chloropyridine

: 3032-92-6
4-cyanophenylacetylene

: 880266-35-3
4-(6-chloropyridine-3-ylethynyl)benzonitrile

Guidance literature:: With copper(l) iodide; diethylamine; triphenylphosphine; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; for 24h; Heating;
DOI:10.1016/j.jorganchem.2005.10.046

Reference yield: 82.0%

: 880266-35-3
4-(6-chloropyridine-3-ylethynyl)benzonitrile

: 880266-36-4
4-(6-iodopyridine-3-ylethynyl)benzonitrile

Guidance literature:: With hydrogen iodide; In dichloromethane; at 0 - 60 ℃; for 12h;
DOI:10.1016/j.jorganchem.2005.10.046

Reference yield:

: 880266-35-3
4-(6-chloropyridine-3-ylethynyl)benzonitrile

: 880266-40-0
4-(6-(naphthalen-1-yl-phenylamino)pyrimidin-3-ylethynyl)benzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: 82 percent / hydroiodide / CH₂Cl₂ / 12 h / 0 - 60 °C

2: 62 percent / t-BuONa; (t-Bu)3P / Pd(dba)2 / toluene / 24 h / Heating

With tri-tert-butyl phosphine; hydrogen iodide; sodium t-butanolate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In dichloromethane; toluene;
DOI:10.1016/j.jorganchem.2005.10.046