5'-O-galactopyranosyl ribavirin

Base Information

• Chemical Name: 5'-O-galactopyranosyl ribavirin
• CAS No.: 114283-62-4
• Molecular Formula: C₁₄H₂₂N₄O₁₀
• Molecular Weight: 406.349
• Mol file: 114283-62-4.mol

Synonyms:5’-O-galactopyranosyl ribavirin

Chemical Property of 5'-O-galactopyranosyl ribavirin

Chemical Property:

• Boiling Point: 833.6°Cat760mmHg
• Flash Point: 457.9°C
• PSA: 222.87000
• Density: 2.14g/cm³
• LogP: -4.48700

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5'-O-galactopyranosyl ribavirin

There total 3 articles about 5'-O-galactopyranosyl ribavirin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

1-<2,3-di-O-acetyl-5-O-(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)-β-D-ribofuranosyl>-1,2,4-triazole-3-carboxamide (114283-61-3) → 1-(5-O-β-D-galactopyranosyl-β-D-ribofuranosyl)-1,2,4-triazole-3-carboxamide (114283-62-4)

Guidance literature:

With ammonia; In ethanol; at 0 ℃;

DOI:10.1016/0008-6215(87)80103-9

Reference yield:

1-(2,3-di-O-acetyl-5-O-trityl-β-D-ribofuranosyl)-1,2,4-triazole-3-carboxamide (114283-58-8) → 1-(5-O-β-D-galactopyranosyl-β-D-ribofuranosyl)-1,2,4-triazole-3-carboxamide (114283-62-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) AgClO₄, drierite / 1) MeNO₂, room temp., 20 min; 2) MeNO₂, 20 degC, 30 min

2: 30 percent / NH₃ / ethanol / 0 °C

With calcium sulfate; ammonia; silver perchlorate; In ethanol;

DOI:10.1016/0008-6215(87)80103-9

Reference yield:

ribavirin (36791-04-5,66510-90-5) → 1-(5-O-β-D-galactopyranosyl-β-D-ribofuranosyl)-1,2,4-triazole-3-carboxamide (114283-62-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 1) pyridine; 2) pyridine / 1) 100 deg C, 3 h; 2) room temp., 20 h

2: 1) AgClO₄, drierite / 1) MeNO₂, room temp., 20 min; 2) MeNO₂, 20 degC, 30 min

3: 30 percent / NH₃ / ethanol / 0 °C

With pyridine; calcium sulfate; ammonia; silver perchlorate; In ethanol;

DOI:10.1016/0008-6215(87)80103-9

upstream raw materials:

1-<2,3-di-O-acetyl-5-O-(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)-β-D-ribofuranosyl>-1,2,4-triazole-3-carboxamide

1-(2,3-di-O-acetyl-5-O-trityl-β-D-ribofuranosyl)-1,2,4-triazole-3-carboxamide

ribavirin