Unii-7R6CR62kfe

Base Information

Chemical Name:Unii-7R6CR62kfe
CAS No.:2503-26-6
Molecular Formula:C30H51 N5 O7
Molecular Weight:593.764
Hs Code.:2933790090
UNII:7R6CR62KFE
Nikkaji Number:J28.634F
Wikidata:Q27268746
ChEMBL ID:CHEMBL4524056
Mol file:2503-26-6.mol

Synonyms:destruxin B

Suppliers and Price of Unii-7R6CR62kfe

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Cayman Chemical
Destruxin B ≥96%
1mg
$ 475.00

Biorbyt Ltd
Destruxinb >98%
200 ug
$ 289.00

Biorbyt Ltd
Destruxinb >98%
1 mg
$ 882.30

ApexBio Technology
DestruxinB
1mg
$ 658.00

American Custom Chemicals Corporation
DESTRUXIN B 95.00%
5MG
$ 500.63

Total 13 raw suppliers

Chemical Property of Unii-7R6CR62kfe

Chemical Property:

Vapor Pressure:4.15E-31mmHg at 25°C
Melting Point:234 °C
Boiling Point:875°Cat760mmHg
PKA:13.54±0.70(Predicted)
Flash Point:483°C
PSA：145.43000
Density:1.17g/cm³
LogP:1.78730
Storage Temp.:-20°C
Solubility.:Soluble in DMSO (up to 10 mg/ml)
XLogP3:2.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:5
Exact Mass:593.37884898
Heavy Atom Count:42
Complexity:1020

Purity/Quality:

97% ^*data from raw suppliers

Destruxin B ≥96% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCC(C)C1C(=O)N(C(C(=O)N(C(C(=O)NCCC(=O)OC(C(=O)N2CCCC2C(=O)N1)CC(C)C)C)C)C(C)C)C
Isomeric SMILES:CC[C@H](C)[C@H]1C(=O)N([C@H](C(=O)N([C@H](C(=O)NCCC(=O)O[C@@H](C(=O)N2CCC[C@H]2C(=O)N1)CC(C)C)C)C)C(C)C)C
Description Destruxin B (2503-26-6) is a cyclic depsipeptide produced by various species of fungi.1 Induces apoptosis in human nonsmall cell lung cancer cells.2 Displays selective cytotoxic effects on human oral cancer cell lines.3 Inhibits hepatocellular carcinoma cell growth via modulation of the Wnt/β-catenin pathway.4
Uses Destruxin B is used as part of destruxin-clausenamide insecticide compounds and its applications in controlling pests. It is also studied for its selective apoptotic cell death effects of oral cancer cells treated with destruxin B.

Technology Process of Unii-7R6CR62kfe

There total 15 articles about Unii-7R6CR62kfe which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 187753-76-0
C₃₀H₅₁N₅O₇N₂H₄(C₅H₈O₂)2

: 2503-26-6
destruxin B

Guidance literature:: C₃₀H₅₁N₅O₇N₂H₄(C₅H₈O₂)2; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 0.5h;

With hydrogenchloride; sodium nitrite; for 0.25h;

With sodium hydrogencarbonate; In dichloromethane; at 20 ℃; for 15h; Further stages.;
DOI:10.1021/jo015953+

Reference yield: 65.0%

: (S)-2-[((S)-2-{[(2S,3S)-2-({(S)-1-[(R)-2-(3-Amino-propionyloxy)-4-methyl-pentanoyl]-pyrrolidine-2-carbonyl}-amino)-3-methyl-pentanoyl]-methyl-amino}-3-methyl-butyryl)-methyl-amino]-propionic acid

: 2503-26-6
destruxin B

Guidance literature:: With sodium hydrogencarbonate; In dichloromethane; water;
DOI:10.1016/S0040-4039(96)02346-5

Reference yield:

: 20312-37-2,498-36-2
(R)-2-hydroxy-4-methylpentanoic acid

: 2503-26-6
destruxin B

Guidance literature:: Multi-step reaction with 5 steps

1.1: 93 percent / DCC; HOBt hydrate / CH₂Cl₂ / 21 h / 0 - 20 °C

2.1: 98 percent / DCC; DMAP / CH₂Cl₂ / 21 h / 0 - 20 °C

3.1: H₂ / Pd/C / methanol / 2 h

4.1: 233 mg / DCC; HOBt hydrate / CH₂Cl₂ / 25 h / 0 - 20 °C

5.1: TFA / CH₂Cl₂ / 0.5 h / 20 °C

5.2: NaNO₂; aq. HCl / 0.25 h

5.3: 65 percent / aq. NaHCO₃ / CH₂Cl₂ / 15 h / 20 °C

With dmap; hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; trifluoroacetic acid; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1021/jo015953+