Carbamic acid, [(1R,2R,6R)-6-(1,3-benzodioxol-5-yl)-2-[[(1,1-dimethylethyl)dimethylsilyl ]oxy]-3-cyclohexen-1-yl]-, methyl ester

Base Information

Chemical Name:Carbamic acid, [(1R,2R,6R)-6-(1,3-benzodioxol-5-yl)-2-[[(1,1-dimethylethyl)dimethylsilyl ]oxy]-3-cyclohexen-1-yl]-, methyl ester
CAS No.:880548-02-7
Molecular Formula:C21H31NO5Si
Molecular Weight:405.566
Hs Code.:

Synonyms:

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Chemical Property of Carbamic acid, [(1R,2R,6R)-6-(1,3-benzodioxol-5-yl)-2-[[(1,1-dimethylethyl)dimethylsilyl ]oxy]-3-cyclohexen-1-yl]-, methyl ester

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Technology Process of Carbamic acid, [(1R,2R,6R)-6-(1,3-benzodioxol-5-yl)-2-[[(1,1-dimethylethyl)dimethylsilyl ]oxy]-3-cyclohexen-1-yl]-, methyl ester

There total 7 articles about Carbamic acid, [(1R,2R,6R)-6-(1,3-benzodioxol-5-yl)-2-[[(1,1-dimethylethyl)dimethylsilyl ]oxy]-3-cyclohexen-1-yl]-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: [(1R,4S,4aR,5R,6R,8aR)-7-Benzo[1,3]dioxol-5-yl-5-(tert-butyl-dimethyl-silanyloxy)-1,4,4a,5,6,8a-hexahydro-1,4-methano-naphthalen-6-yl]-carbamic acid methyl ester

: 880548-02-7
[(1R,2R,6R)-6-Benzo[1,3]dioxol-5-yl-2-(tert-butyl-dimethyl-silanyloxy)-cyclohex-3-enyl]-carbamic acid methyl ester

Guidance literature:: With diphenylether; sodium hydrogencarbonate; for 0.2h; Heating;
DOI:10.3987/COM-05-S(K)68

Reference yield:

: C₁₈H₁₅BrO₄

: 880548-02-7
[(1R,2R,6R)-6-Benzo[1,3]dioxol-5-yl-2-(tert-butyl-dimethyl-silanyloxy)-cyclohex-3-enyl]-carbamic acid methyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: 86 percent / DIBAH; 2,6-di-tert-butyl-4-methylphenol / CH₂Cl₂ / 1.5 h / -78 °C

2.1: 76 percent / (PhO)2PON₃; PPh₃; DIAD / 2 h / 20 °C

3.1: 95 percent / H₂ / Pd/C / ethyl acetate / 10 h / 20 °C

4.1: aq. NaOH / tetrahydrofuran / 1.5 h / 20 °C

4.2: H₂ / Pd(OH)2/C / methanol / 20 °C

5.1: 94 percent / Zn; AcOH / methanol; tetrahydrofuran / 2.5 h / Heating

6.1: 95 percent / Et₃N / CH₂Cl₂ / 2 h / -78 °C

7.1: 87 percent / NaHCO₃; Ph₂O / 0.2 h / Heating

With sodium hydroxide; diphenylether; 2,6-di-tert-butyl-4-methyl-phenol; di-isopropyl azodicarboxylate; diphenyl phosphoryl azide; hydrogen; diisobutylaluminium hydride; sodium hydrogencarbonate; acetic acid; triethylamine; triphenylphosphine; zinc; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; 2.1: Mitsunobu reaction;
DOI:10.3987/COM-05-S(K)68

Reference yield:

: C₁₈H₁₆BrN₃O₃

: 880548-02-7
[(1R,2R,6R)-6-Benzo[1,3]dioxol-5-yl-2-(tert-butyl-dimethyl-silanyloxy)-cyclohex-3-enyl]-carbamic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: 95 percent / H₂ / Pd/C / ethyl acetate / 10 h / 20 °C

2.1: aq. NaOH / tetrahydrofuran / 1.5 h / 20 °C

2.2: H₂ / Pd(OH)2/C / methanol / 20 °C

3.1: 94 percent / Zn; AcOH / methanol; tetrahydrofuran / 2.5 h / Heating

4.1: 95 percent / Et₃N / CH₂Cl₂ / 2 h / -78 °C

5.1: 87 percent / NaHCO₃; Ph₂O / 0.2 h / Heating

With sodium hydroxide; diphenylether; hydrogen; sodium hydrogencarbonate; acetic acid; triethylamine; zinc; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate;
DOI:10.3987/COM-05-S(K)68