GW 6471

Base Information

• Chemical Name: GW 6471
• CAS No.: 880635-03-0
• Deprecated CAS: 436159-64-7
• Molecular Formula: C35H36F3N3O4
• Molecular Weight: 619.67300
• European Community (EC) Number: 636-961-3,804-305-7
• DSSTox Substance ID: DTXSID601014896
• Nikkaji Number: J1.701.785C
• Wikidata: Q27077951
• Pharos Ligand ID: KJX56UUYZWPY
• ChEMBL ID: CHEMBL500272
• Mol file: 880635-03-0.mol

Synonyms:GW 6471;GW6471

Chemical Property of GW 6471

Chemical Property:

• PKA: 15.90±0.46(Predicted)
• PSA: 96.95000
• Density: 1.204±0.06 g/cm3(Predicted)
• LogP: 8.33510
• Storage Temp.: 2-8°C
• Solubility.: DMSO: 15 mg/mL
• XLogP3: 7.9
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 9
• Rotatable Bond Count: 14
• Exact Mass: 619.26579112
• Heavy Atom Count: 45
• Complexity: 954

Purity/Quality:

99% ^*data from raw suppliers

GW 6471 ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCC(=O)NCC(CC1=CC=C(C=C1)OCCC2=C(OC(=N2)C3=CC=CC=C3)C)NC(=CC(=O)C4=CC=C(C=C4)C(F)(F)F)C
• Isomeric SMILES: CCC(=O)NC[C@H](CC1=CC=C(C=C1)OCCC2=C(OC(=N2)C3=CC=CC=C3)C)N/C(=C\C(=O)C4=CC=C(C=C4)C(F)(F)F)/C
• Uses: GW 6471 is a potent antagonist of PPARα with IC50 of 0.24 μM. GW 6471 is a peroxisome proliferator-activated receptor α (PPARα) antagonist. GW 6471 has been shown to enhance the binding affinity of the PPARα ligand-binding domain to the co-repressor proteins SMRT and NCoR.