1H-2-Benzazepin-1-one, 8-(2,4-difluorophenoxy)-2-[(1S)-1-(1,4-dioxaspiro[4.5]dec-8-ylmethyl)-2- methylpropyl]-2,3,4,5-tetrahydro-

Base Information

Chemical Name:1H-2-Benzazepin-1-one, 8-(2,4-difluorophenoxy)-2-[(1S)-1-(1,4-dioxaspiro[4.5]dec-8-ylmethyl)-2- methylpropyl]-2,3,4,5-tetrahydro-
CAS No.:881210-71-5
Molecular Formula:C29H35F2NO4
Molecular Weight:499.598
Hs Code.:

Synonyms:

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Chemical Property of 1H-2-Benzazepin-1-one, 8-(2,4-difluorophenoxy)-2-[(1S)-1-(1,4-dioxaspiro[4.5]dec-8-ylmethyl)-2- methylpropyl]-2,3,4,5-tetrahydro-

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Technology Process of 1H-2-Benzazepin-1-one, 8-(2,4-difluorophenoxy)-2-[(1S)-1-(1,4-dioxaspiro[4.5]dec-8-ylmethyl)-2- methylpropyl]-2,3,4,5-tetrahydro-

There total 15 articles about 1H-2-Benzazepin-1-one, 8-(2,4-difluorophenoxy)-2-[(1S)-1-(1,4-dioxaspiro[4.5]dec-8-ylmethyl)-2- methylpropyl]-2,3,4,5-tetrahydro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 881210-70-4
C₃₀H₃₉F₂NO₅

: 881210-71-5
C₂₉H₃₅F₂NO₄

Guidance literature:: C₃₀H₃₉F₂NO₅; With methanol; lithium hydroxide; water; at 80 ℃; for 2h;

With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 40 ℃; for 2h;

Reference yield:

: 1308600-38-5
C₁₄H₁₁F₂NO₃

: 881210-71-5
C₂₉H₃₅F₂NO₄

Guidance literature:: Multi-step reaction with 4 steps

1: cis-nitrous acid; potassium iodide / ethanol

2: palladium diacetate; triethylamine / tetrahydrofuran

3: sodium tris(acetoxy)borohydride / dichloromethane

4: N,N-dimethyl-formamide / 50 - 60 °C

With palladium diacetate; cis-nitrous acid; sodium tris(acetoxy)borohydride; triethylamine; potassium iodide; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2012.01.014

Reference yield:

: 320-98-9
5-fluoro-2-nitrobenzoic acid

: 881210-71-5
C₂₉H₃₅F₂NO₄

Guidance literature:: Multi-step reaction with 7 steps

1: caesium carbonate / N,N-dimethyl-formamide / 100 °C

2: methanol / diethyl ether

3: palladium on activated charcoal; hydrogen / ethanol

4: cis-nitrous acid; potassium iodide / ethanol

5: palladium diacetate; triethylamine / tetrahydrofuran

6: sodium tris(acetoxy)borohydride / dichloromethane

7: N,N-dimethyl-formamide / 50 - 60 °C

With methanol; palladium on activated charcoal; hydrogen; palladium diacetate; cis-nitrous acid; sodium tris(acetoxy)borohydride; caesium carbonate; triethylamine; potassium iodide; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2012.01.014