Technology Process of 2H-Azepin-2-one, hexahydro-5,6-dimethyl-4-phenyl-1-(phenylmethyl)-,
(4R,5S,6R)-
There total 7 articles about 2H-Azepin-2-one, hexahydro-5,6-dimethyl-4-phenyl-1-(phenylmethyl)-,
(4R,5S,6R)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogen;
palladium dihydroxide;
In
ethanol;
at 20 ℃;
for 12h;
under 2585.74 Torr;
Title compound not separated from byproducts;
DOI:10.1021/ja057592b
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: Me3Al / CH2Cl2; hexane / 0.25 h
1.2: CH2Cl2; hexane / 40 h / 40 °C
2.1: aq. HCl / CHCl3 / 24 h
3.1: H2 / Pd(OH)2 / ethanol / 12 h / 20 °C / 2585.74 Torr
With
hydrogenchloride; hydrogen; trimethylaluminum;
palladium dihydroxide;
In
ethanol; hexane; dichloromethane; chloroform;
DOI:10.1021/ja057592b
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 95 percent / Et3N / CH2Cl2 / 13 h / 0 - 20 °C
2.1: (-)-sparteine; n-BuLi / toluene / 1 h / -78 °C
2.2: toluene / 3 h / -78 °C
3.1: Me3Al / CH2Cl2; hexane / 0.25 h
3.2: CH2Cl2; hexane / 40 h / 40 °C
4.1: aq. HCl / CHCl3 / 24 h
5.1: H2 / Pd(OH)2 / ethanol / 12 h / 20 °C / 2585.74 Torr
With
hydrogenchloride; n-butyllithium; hydrogen; trimethylaluminum; triethylamine; (-)-sparteine;
palladium dihydroxide;
In
ethanol; hexane; dichloromethane; chloroform; toluene;
DOI:10.1021/ja057592b
