2,4(1H,3H)-Pyrimidinedione, 1-((2-hydroxyethoxy)methyl)-5-((1Z)-2-phenylethenyl)-6-(phenylthio)-

Base Information

Chemical Name:2,4(1H,3H)-Pyrimidinedione, 1-((2-hydroxyethoxy)methyl)-5-((1Z)-2-phenylethenyl)-6-(phenylthio)-
CAS No.:131194-26-8
Molecular Formula:C21H20 N2 O4 S
Molecular Weight:396.4595
Hs Code.:
Nikkaji Number:J362.155C

Synonyms:1-(2OHEtOMe)-6PhS-5PhVinylU;131194-26-8;2,4(1H,3H)-Pyrimidinedione, 1-((2-hydroxyethoxy)methyl)-5-((1Z)-2-phenylethenyl)-6-(phenylthio)-;1-((2-Hydroxyethoxy)methyl)-6-(phenylthio)-5-(2-(Z)-phenylvinyl)uracil;1-[(2-Hydroxyethoxy)methyl]-6-(phenylthio)-5-[2-(Z)-phenylvinyl]uracil;2,4(1H,3H)-Pyrimidinedione, 1-[(2-hydroxyethoxy)methyl]-5-[(1Z)-2-phenylethenyl]-6-(phenylthio)-;1-(2-Hydroxyethoxymethyl)-6-phenylthio-5-[(Z)-2-phenylethenyl]uracil;1-(2-hydroxyethoxymethyl)-6-phenylsulfanyl-5-[(Z)-styryl]pyrimidine-2,4-dione

Suppliers and Price of 2,4(1H,3H)-Pyrimidinedione, 1-((2-hydroxyethoxy)methyl)-5-((1Z)-2-phenylethenyl)-6-(phenylthio)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of 2,4(1H,3H)-Pyrimidinedione, 1-((2-hydroxyethoxy)methyl)-5-((1Z)-2-phenylethenyl)-6-(phenylthio)-

Chemical Property:

Boiling Point:°Cat760mmHg
Flash Point:°C
Density:1.36g/cm³
XLogP3:3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:8
Exact Mass:396.11437830
Heavy Atom Count:28
Complexity:608

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C=C1)C=CC2=C(N(C(=O)NC2=O)COCCO)SC3=CC=CC=C3
Isomeric SMILES:C1=CC=C(C=C1)/C=C\C2=C(N(C(=O)NC2=O)COCCO)SC3=CC=CC=C3

Technology Process of 2,4(1H,3H)-Pyrimidinedione, 1-((2-hydroxyethoxy)methyl)-5-((1Z)-2-phenylethenyl)-6-(phenylthio)-

There total 4 articles about 2,4(1H,3H)-Pyrimidinedione, 1-((2-hydroxyethoxy)methyl)-5-((1Z)-2-phenylethenyl)-6-(phenylthio)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.0%

: 125056-93-1
1-[(2-hydroxyethoxy)methyl]-5-(2-phenylethynyl)-6-phenylthiouracil

: 131194-26-8
1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)-5-(2-(Z)-phenylvinyl)uracil

Guidance literature:: With hydrogen; acetic acid; palladium on barium sulfate; In ethanol; for 0.0333333h; under 760 Torr; Ambient temperature;
DOI:10.1021/jm00105a055

Reference yield:

: 123027-47-4
1-<<2-(tert-butyldimethylsiloxy)ethoxy>methyl>-6-(phenylthio)uracil

: 131194-26-8
1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)-5-(2-(Z)-phenylvinyl)uracil

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) lithium 2,2,6,6-tetramethylpiperidide (LTMP), 2.) iodine / 1.) THF, -70 deg C, 1 h, 2.) -70 deg C, 1 h

2: 1.) Et₃N, bis(triphenylphosphine)palladium(II) chloride, copper(I) iodide / 1.) THF, 60 deg C, 2 h, 2.) 60 deg C, 1.5 h

3: AcOH, H₂O / tetrahydrofuran / 14 h / Ambient temperature

4: 24 percent / H₂, AcOH / 10percent Pd-BaSO₄ / ethanol / 0.03 h / 760 Torr / Ambient temperature

With copper(l) iodide; bis(triphenylphosphine)palladium(II)-chloride; 2,2,6,6-tetramethylpiperidinyl-lithium; water; hydrogen; iodine; acetic acid; triethylamine; palladium on barium sulfate; In tetrahydrofuran; ethanol;
DOI:10.1021/jm00105a055

Reference yield:

: 125057-21-8
1-<<2-<(tert-butyldimethylsilyl)oxy>ethoxy>methyl>-5-iodo-6-(phenylthio)uracil

: 131194-26-8
1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)-5-(2-(Z)-phenylvinyl)uracil

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) Et₃N, bis(triphenylphosphine)palladium(II) chloride, copper(I) iodide / 1.) THF, 60 deg C, 2 h, 2.) 60 deg C, 1.5 h

2: AcOH, H₂O / tetrahydrofuran / 14 h / Ambient temperature

3: 24 percent / H₂, AcOH / 10percent Pd-BaSO₄ / ethanol / 0.03 h / 760 Torr / Ambient temperature

With copper(l) iodide; bis(triphenylphosphine)palladium(II)-chloride; water; hydrogen; acetic acid; triethylamine; palladium on barium sulfate; In tetrahydrofuran; ethanol;
DOI:10.1021/jm00105a055